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  1. Link

    corticosterone-endogenous-steroid-hormone-ab143597.pdf

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Epigenetics and Nuclear Signaling Transcription Domain Families Zinc Finger
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Corticosterone, endogenous steroid hormone (ab143597)

  • Datasheet
  • SDS
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Key features and details

  • Potent endogenous glucocorticoid and mineralocorticoid receptor agonist
  • CAS Number: 50-22-6
  • Purity: > 96%
  • Soluble in DMSO to 100 mM and in ethanol to 10 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Corticosterone, endogenous steroid hormone
  • Description

    Potent endogenous glucocorticoid and mineralocorticoid receptor agonist
  • Biological description

    Potent endogenous glucocorticoid and mineralocorticoid receptor agonist (EC50 = 20 nM, GR). Induces apoptosis. Modulates carbohydrate, potassium, and sodium metabolism in vivo. Blood-brain barrier permeable.
  • Purity

    > 96%
  • CAS Number

    50-22-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (8S,9S,10R,11S,13S,14S,17S)-11-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
  • Molecular weight

    346.46
  • Molecular formula

    C21H30O4
  • PubChem identifier

    5753
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O
  • Source

    Synthetic

  • Research areas

    • Epigenetics and Nuclear Signaling
    • Transcription
    • Domain Families
    • Zinc Finger
    • Neuroscience
    • Neurology process
    • Neural Signal Transduction
    • Signal Transduction
    • Signaling Pathway
    • Nuclear Signaling
    • Nuclear Hormone Receptors
    • Progesterone
    • Signal Transduction
    • Signaling Pathway
    • Nuclear Signaling
    • Nuclear Hormone Receptors
    • Corticoid
    • Signal Transduction
    • Signaling Pathway
    • Nuclear Signaling
    • Nuclear Hormone Receptors
    • Testosterone
    • Signal Transduction
    • Growth Factors/Hormones
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    • Channels
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    • Gonadotrophic axis
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    • Epigenetics and Nuclear Signaling
    • Nuclear Signaling Pathways
    • Nuclear Receptors
    • Corticoid
    • Epigenetics and Nuclear Signaling
    • Nuclear Signaling Pathways
    • Nuclear Receptors
    • Progesterone
    • Epigenetics and Nuclear Signaling
    • Nuclear Signaling Pathways
    • Nuclear Receptors
    • Testosterone
    • Epigenetics and Nuclear Signaling
    • Transcription
    • Other factors
    • Signal Transduction
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    • Apoptosis & cell cycle
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    • Receptors & Transporters
    • Nuclear Receptors
    • Glucocorticoid
    • Biochemicals
    • Pharmacology
    • Receptors & Transporters
    • Nuclear Receptors
    • Mineralocorticoid
    • Metabolism
    • Pathways and Processes
    • Mitochondrial Metabolism
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Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

    • Datasheet
    • SDS
  • References (2)

    Publishing research using ab143597? Please let us know so that we can cite the reference in this datasheet.

    ab143597 has been referenced in 2 publications.

    • Li M  et al. Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root Ganglion Neurons Innervating the Rat Stomach. J Neurogastroenterol Motil 23:464-476 (2017). Rat . PubMed: 28343377
    • Perry RJ  et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell 160:745-758 (2015). PubMed: 25662011

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