Corticosterone, endogenous steroid hormone (ab143597)
- Datasheet
- References (2)
Overview
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Product name
Corticosterone, endogenous steroid hormone -
Description
Potent endogenous glucocorticoid and mineralocorticoid receptor agonist -
Biological description
Potent endogenous glucocorticoid and mineralocorticoid receptor agonist (EC50 = 20 nM, GR). Induces apoptosis. Modulates carbohydrate, potassium, and sodium metabolism in vivo. Blood-brain barrier permeable. -
Purity
> 96% -
CAS Number
50-22-6 -
Chemical structure
Properties
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Chemical name
(8S,9S,10R,11S,13S,14S,17S)-11-Hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one -
Molecular weight
346.46 -
Molecular formula
C21H30O4 -
PubChem identifier
5753 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and in ethanol to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4C(=O)CO)C)O -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Mora F et al. Stress, neurotransmitters, corticosterone and body-brain integration. Brain Res 1476:71-85 (2012). Read more (PubMed: 22285436) »
- Schoffelmeer AN et al. Glucocorticoid receptor activation potentiates the morphine-induced adaptive increase in dopamine D-1 receptor efficacy in gamma-aminobutyric acid neurons of rat striatum/nucleus accumbens. J Pharmacol Exp Ther 274:1154-60 (1995). Read more (PubMed: 7562482) »
- Ronken E et al. Glucocorticoid and mineralocorticoid receptors differentially modulate cultured dopaminergic neurons of rat ventral mesencephalon. Eur J Pharmacol 263:149-56 (1994). Read more (PubMed: 7821346) »
