Overview

  • Product name

    Cortistatin-14, Endogenous neuropeptide
  • Description

    Endogenous neuropeptide that binds all SS receptor subtypes
  • Biological description

    Endogenous neuropeptide, expressed in the cortex and hippocampus. Structural and functional similarities to somatostatin-14. Binds all somatostatin receptors (IC50 values are 5 (sst1), 0.09 (sst2), 0.3 (sst3), 0.2 (sst4) and 0.3 (sst5) nM respectively). Neuronal depressant and sleep-modulating properties in vivo. Important mediator of immunity and inflammation.
  • Purity

    > 95%
  • CAS Number

    186901-48-4
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    1721.02
  • Molecular formula

    C81H113N19O19S2
  • Sequence

    PCKNFFWKTFSSCK (Modifications: Disulfide bonds: 2-13)
  • PubChem identifier

    16133803
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)CC5=CC=CC=C5)CC(=O)N)CCCCN)NC(=O)C6CCCN6)C(=O)NC(CCCCN)C(=O)O)CO)CO)CC7=CC=CC=C7)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Markovics A  et al. Comparison of the anti-inflammatory and anti-nociceptive effects of cortistatin-14 and somatostatin-14 in distinct in vitro and in vivo model systems. J Mol Neurosci 46:40-50 (2012). Read more (PubMed: 21695504) »
  • de Lecea L Cortistatin--functions in the central nervous system. Mol Cell Endocrinol 286:88-95 (2008). Read more (PubMed: 18374474) »
  • Spier AD & de Lecea L Cortistatin: a member of the somatostatin neuropeptide family with distinct physiological functions. Brain Res Brain Res Rev 33:228-41 (2000). Read more (PubMed: 11011067) »

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