Corydaline, Acetylcholinesterase (AChE) inhibitor (ab145574)

Overview

  • Product name

    Corydaline, Acetylcholinesterase (AChE) inhibitor
  • Description

    Acetylcholinesterase (AChE) inhibitor. Exhibits gastrointestinal modulatory, antinociceptive, antiallergy and antiparasitic activities.
  • Alternative names

    • (+)-Corydaline
    • Corydalin
    • D-Corydaline
  • Biological description

    Alkaloid compound isolated from Corydalis tubers. Exhibits gastrointestinal modulatory, antinociceptive, anti-allergic, and anti-parasitic activities. Currently in clinical trials as a potential treatment for functional dyspepsia. Exhibits nematocidal activity against species of Strongyloides.

  • Purity

    > 95%
  • CAS Number

    518-69-4
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    369.45
  • Molecular formula

    C22H27NO4
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1C2C3=CC(=C(C=C3CCN2CC4=C1C=CC(=C4OC)OC)OC)OC
  • Source

    Corydalis sp.

References

This product has been referenced in:

  • Lee TH  et al. Effects of corydaline from Corydalis tuber on gastric motor function in an animal model. Biol Pharm Bull 33:958-62 (2010). Read more (PubMed: 20522959) »
  • Wang C  et al. Screening of antinociceptive components in Corydalis yanhusuo W.T. Wang by comprehensive two-dimensional liquid chromatography/tandem mass spectrometry. Anal Bioanal Chem 396:1731-40 (2010). Read more (PubMed: 20101504) »
  • Adsersen A  et al. Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Corydalis cava Schweigg. & Kort. J Ethnopharmacol 113:179-82 (2007). Read more (PubMed: 17574358) »
  • Saito SY  et al. The combination of rat mast cell and rabbit aortic smooth muscle is the simple bioassay for the screening of anti-allergic ingredient from methanolic extract of Corydalis tuber. Biol Pharm Bull 27:1270-4 (2004). Read more (PubMed: 15305035) »
  • Satou T  et al. Assay of nematocidal activity of isoquinoline alkaloids using third-stage larvae of Strongyloides ratti and S. venezuelensis. Vet Parasitol 104:131-8 (2002). Read more (PubMed: 11809332) »

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