Corynoline, Acetylcholinesterase (AChE) inhibitor (ab145575)

Overview

  • Product name

    Corynoline, Acetylcholinesterase (AChE) inhibitor
  • Description

    Acetylcholinesterase (AChE) inhibitor
  • Alternative names

    • (+)-Corynoline
    • 13-Methylchelidonine
  • Biological description

    Alkaloid compound isolated from Corydalis tubers. Anticancer activity. Exhibits cytotoxicity against several types of cancers in vitro, including lung carcinoma, colon carcinoma, melanoma, and ovarian carcinoma cell lines. Non-competitively inhibits acetylcholinesterase (AChE) in vitro (IC50 = 30.6 mM).

  • Purity

    > 98%
  • CAS Number

    18797-79-0
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    367.40
  • Molecular formula

    C21H21NO5
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC12C(CC3=CC4=C(C=C3C1N(CC5=C2C=CC6=C5OCO6)C)OCO4)O
  • Source

    Corydalis sp.

References

This product has been referenced in:

  • Fang ZZ  et al. Identification of cytochrome P450 (CYP) isoforms involved in the metabolism of corynoline, and assessment of its herb-drug interactions. Phytother Res 25:256-63 (2011). Read more (PubMed: 20641061) »
  • Choi SU  et al. Cytotoxic isoquinoline alkaloids from the aerial parts of Corydalis incisa. Arch Pharm Res 30:151-4 (2007). Read more (PubMed: 17366734) »
  • Kim DK Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res 25:817-9 (2002). Read more (PubMed: 12510831) »

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