Product nameCorynoline, Acetylcholinesterase (AChE) inhibitor
DescriptionAcetylcholinesterase (AChE) inhibitor
Alkaloid compound isolated from Corydalis tubers. Anticancer activity. Exhibits cytotoxicity against several types of cancers in vitro, including lung carcinoma, colon carcinoma, melanoma, and ovarian carcinoma cell lines. Non-competitively inhibits acetylcholinesterase (AChE) in vitro (IC50 = 30.6 mM).
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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This product has been referenced in:
- Fang ZZ et al. Identification of cytochrome P450 (CYP) isoforms involved in the metabolism of corynoline, and assessment of its herb-drug interactions. Phytother Res 25:256-63 (2011). Read more (PubMed: 20641061) »
- Choi SU et al. Cytotoxic isoquinoline alkaloids from the aerial parts of Corydalis incisa. Arch Pharm Res 30:151-4 (2007). Read more (PubMed: 17366734) »
- Kim DK Inhibitory effect of corynoline isolated from the aerial parts of Corydalis incisa on the acetylcholinesterase. Arch Pharm Res 25:817-9 (2002). Read more (PubMed: 12510831) »