Overview

  • Product name

    Costunolide, FPTase and telomerase inhibitor
  • Description

    FPTase and telomerase inhibitor. Apoptotic agent.
  • Biological description

    FPTase and telomerase inhibitor (IC50 values are 20 and 60-90 μM respectively). Apoptotic agent. Induces ROS production, activation of caspases, down-regulation of Bcl-2. Increases mitochondrial permeability transition and cytochrome C release. Shows normo-glycemic and hypolipidemic activity in vivo. Orally active.
  • Purity

    > 97%
  • CAS Number

    553-21-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (3aS,6E,10E,11aR)-6,10-Dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one
  • Molecular weight

    232.32
  • Molecular formula

    C15H20O2
  • PubChem identifier

    5281437
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1C/C(=C/[C@@H]2[C@@H](CC/C(=C/1)C)C(C(O2)=O)=C)C
  • Source

    Saussurea costus

  • Research areas

References

This product has been referenced in:

  • Zhang J  et al. Pharmacokinetic study on costunolide and dehydrocostuslactone after oral administration of traditional medicine Aucklandia lappa Decne. by LC/MS/MS. J Ethnopharmacol 151:191-7 (2014). Read more (PubMed: 24216164) »
  • Yang YI  et al. Costunolide induces apoptosis in platinum-resistant human ovarian cancer cells by generating reactive oxygen species. Gynecol Oncol 123:588-96 (2011). Read more (PubMed: 21945308) »
  • Eliza J  et al. Normo-glycemic and hypolipidemic effect of costunolide isolated from Costus speciosus (Koen ex. Retz.)Sm. in streptozotocin-induced diabetic rats. Chem Biol Interact 179:329-34 (2009). Read more (PubMed: 19007766) »
  • Choi SH  et al. Inhibitory effects of costunolide on the telomerase activity in human breast carcinoma cells. Cancer Lett 227:153-62 (2005). Read more (PubMed: 16112418) »

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