Overview

  • Product name

    Coumestrol, anti-estrogenic agent
  • Description

    Potent atypical anti-estrogenic agent.17-β−hydroxysteroid oxidoreductase inhibitor
  • Biological description

    Potent atypical anti-estrogenic agent. 17-β−hydroxysteroid oxidoreductase inhibitor. Competitively binds with higher affinity to ERβ than ERα. Inhibits transcriptional activity of both ER subtypes (IC50 = 1-10 nM). Activates Sirt1. Induces mitochondrial biogenesis. Shows antioxidant and neuroprotective effects in vivo. Orally active.
  • Purity

    > 97%
  • CAS Number

    479-13-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Castro CC  et al. Coumestrol treatment prevents Na+, K+ -ATPase inhibition and affords histological neuroprotection to male rats receiving cerebral global ischemia. Neurol Res 36:198-206 (2014). Read more (PubMed: 24512013) »
  • Seo DB  et al. Coumestrol Induces Mitochondrial Biogenesis by Activating Sirt1 in Cultured Skeletal Muscle Cells. J Agric Food Chem : (2014). Read more (PubMed: 24712520) »
  • Kuiper GG  et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta. Endocrinology 139:4252-63 (1998). Read more (PubMed: 9751507) »
  • Markaverich BM  et al. Effects of coumestrol on estrogen receptor function and uterine growth in ovariectomized rats. Environ Health Perspect 103:574-81 (1995). Read more (PubMed: 7556010) »

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