Description

  • Product name

    Cow truncated GARP peptide
  • Animal free

    No
  • Nature

    Synthetic
    • Species

      Cow
    • Sequence

      CDVQTRVVAAGSL
    • Amino acids

      287 to 299

Specifications

Our Abpromise guarantee covers the use of ab39811 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

    Neutralising

  • Form

    Lyophilised
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Reconstitute with 0.1 ml of distilled water.

General Info

  • Alternative names

    • 240 kDa protein of rod photoreceptor CNG channel
    • cGMP gated cation channel beta subunit
    • CNCG 4
    • CNCG2
    • CNCG3L
    • CNCG4
    • CNG 4
    • CNG channel 4
    • CNG channel beta 1
    • CNG4
    • CNGB 1
    • CNGB1
    • CNGB1B
    • Cyclic nucleotide gated cation channel
    • Cyclic nucleotide gated cation channel 4
    • Cyclic nucleotide gated cation channel beta 1
    • Cyclic nucleotide gated cation channel gamma
    • Cyclic nucleotide gated cation channel modulatory subunit
    • Cyclic nucleotide gated channel (photoreceptor) cGMP gated 3 (gamma) like
    • Cyclic nucleotide gated channel beta 1
    • GAR1
    • GARP
    • GARP2
    • Glutamic acid rich protein
    • RCNC2
    • RCNCb
    • RCNCbeta
    • RP45
    • Truncated glutamic acid rich protein
    • Truncated rod photoreceptor cGMP gated channel beta subunit
    see all
  • Relevance

    Glutamic acid rich protein (GARP) is a soluble protein localized to the outer segments of the rod photoreceptor. It forms a subunit of cyclic nucleotide-gated (CNG) channels, nonselective cation channels, which play important roles in both visual and olfactory signal transduction. When associated with CNGA1, it is involved in the regulation of ion flow into the rod photoreceptor outer segment (ROS), in response to light-induced alteration of the levels of intracellular cGMP. There are 3 isoforms produced by alternative splicing. Isoform GARP2 is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties; it is a regulator of spontaneous activation of rod PDE6, thereby serving to lower rod photoreceptor 'dark noise' and allowing these sensory cells to operate at the single photon detection limit. Defects in GARP are the cause of retinitis pigmentosa type 25 (RP25). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • Cellular localization

    Membrane; Multi-pass membrane protein.

References

ab39811 has not yet been referenced specifically in any publications.

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