Anti-Cox-3 antibody (ab37269)
Key features and details
- Rabbit polyclonal to Cox-3
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-Cox-3 antibody -
Description
Rabbit polyclonal to Cox-3 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
Synthetic peptide corresponding to residues from the N-terminus of Cox-3 (Mouse).
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Positive control
- mouse small intestinal tissue
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General notes
This product is manufactured by BioVision, an Abcam company and was previously called 3687 Cox-3 Antibody. 3687-100 is the same size as the 100 µg size of ab37269.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Preservative: 0.02% Thimerosal (merthiolate)
Constituents: 1% BSA, 50% Glycerol (glycerin, glycerine), PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab37269 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use at an assay dependent concentration. Predicted molecular weight: 69 kDa.
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Notes |
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WB
Use at an assay dependent concentration. Predicted molecular weight: 69 kDa. |
Target
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Relevance
COX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (nonsteroidal anti-inflammatory drugs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throughout the body, whereas PGs formed by COX-2 primarily mediate pain, fever, and inflammation. COX-1 is constitutively expressed, with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis. In rodents and humans, COX-3 encodes proteins with completely different amino acid sequences from COX-1 or COX-2, and without COX activity. COX-3 is thought to be a splice variant of COX-1 which retains intron one. It has been suggested that COX-3 may be the key to unlocking the mechanism of action of acetaminophen. -
Cellular localization
Membrane-associated; Microsomal membrane. -
Database links
- Entrez Gene: 19224 Mouse
- SwissProt: P22437 Mouse
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Alternative names
- Cox3 antibody
- Cyclooxygenase 1 antibody
- Ptgs1 antibody
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab37269 has been referenced in 1 publication.
- Cui TZ et al. Modulation of the respiratory supercomplexes in yeast: enhanced formation of cytochrome oxidase increases the stability and abundance of respiratory supercomplexes. J Biol Chem 289:6133-41 (2014). WB ; Saccharomyces cerevisiae . PubMed: 24421313