Anti-Cox-3 antibody (ab37269)
- Datasheet
- References (1)
- Protocols
Overview
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Product nameAnti-Cox-3 antibody
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DescriptionRabbit polyclonal to Cox-3
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Host speciesRabbit
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Specificityab37269 recognizes COX-3.
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Tested applicationsSuitable for: WBmore details
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Species reactivityReacts with: Mouse
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Immunogen
Synthetic peptide corresponding to residues from the N-terminus of Cox-3 (Mouse).
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Positive control
- mouse small intestinal tissue
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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Storage bufferPreservative: 0.02% Thimerosal (merthiolate)
Constituents: 1% BSA, 50% Glycerol, PBS -
Concentration information loading... -
PurityImmunogen affinity purified
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ClonalityPolyclonal
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IsotypeIgG
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Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab37269 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | Use a concentration of 1 - 4 µg/ml. Predicted molecular weight: 30 kDa. |
Target
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RelevanceCOX proteins are membrane-associated heme proteins that have cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (nonsteroidal anti-inflammatory drugs) such as aspirin. Prostaglandins (PGs) formed by the enzymatic activity of COX-1 are primarily involved in the regulation of homeostatic functions throughout the body, whereas PGs formed by COX-2 primarily mediate pain, fever, and inflammation. COX-1 is constitutively expressed, with particularly high expression in gastrointestinal tissues. COX-2 is induced by cytokines and mitogens and is likely to play a role in inflammatory diseases such as rheumatoid arthritis. In rodents and humans, COX-3 encodes proteins with completely different amino acid sequences from COX-1 or COX-2, and without COX activity. COX-3 is thought to be a splice variant of COX-1 which retains intron one. It has been suggested that COX-3 may be the key to unlocking the mechanism of action of acetaminophen.
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Cellular localizationMembrane-associated; Microsomal membrane.
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Database links
- Entrez Gene: 19224 Mouse
- SwissProt: P22437 Mouse
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Alternative names
- Cox3 antibody
- Cyclooxygenase 1 antibody
- Ptgs1 antibody
Protocols
References
This product has been referenced in:
- Cui TZ et al. Modulation of the respiratory supercomplexes in yeast: enhanced formation of cytochrome oxidase increases the stability and abundance of respiratory supercomplexes. J Biol Chem 289:6133-41 (2014). WB ; Saccharomyces cerevisiae . Read more (PubMed: 24421313) »
