Recombinant
RabMAb

Recombinant Anti-COX1 / Cyclooxygenase 1 antibody [EPR5867] (ab133319)

Overview

  • Product name

    Anti-COX1 / Cyclooxygenase 1 antibody [EPR5867]
    See all COX1 / Cyclooxygenase 1 primary antibodies
  • Description

    Rabbit monoclonal [EPR5867] to COX1 / Cyclooxygenase 1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
    Unsuitable for: Flow Cyt,ICC or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human COX1/ Cyclooxygenase 1 aa 500-600. The exact sequence is proprietary.

  • Positive control

    • C2C12, A431, NIH 3T3, Neuro 2a, and L6 cell lysates; Human stomach tissue.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab133319 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Detects a band of approximately 65-70 kDa (predicted molecular weight: 68 kDa).
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
  • Application notes
    Is unsuitable for Flow Cyt,ICC or IP.
  • Target

    • Function

      May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
    • Pathway

      Lipid metabolism; prostaglandin biosynthesis.
    • Sequence similarities

      Belongs to the prostaglandin G/H synthase family.
      Contains 1 EGF-like domain.
    • Cellular localization

      Microsome membrane. Endoplasmic reticulum membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • COX 1 antibody
      • COX 3 antibody
      • COX-1 antibody
      • COX1 antibody
      • Cox3 antibody
      • Cyclooxygenase 1 antibody
      • Cyclooxygenase 3, included antibody
      • Cyclooxygenase-1 antibody
      • EC 1.14.99.1 antibody
      • Partial COX1 proteins, included antibody
      • PCOX1 antibody
      • PGG/HS antibody
      • PGH synthase 1 antibody
      • PGH1_HUMAN antibody
      • PGHS-1 antibody
      • PGHS1 antibody
      • PHS 1 antibody
      • PHS1 antibody
      • Prostaglandin G/H synthase 1 antibody
      • Prostaglandin H2 synthase 1 antibody
      • Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) antibody
      • Prostaglandin-endoperoxide synthase 1 antibody
      • PTGHS antibody
      • PTGS1 antibody
      see all

    Images

    • All lanes : Anti-COX1 / Cyclooxygenase 1 antibody [EPR5867] (ab133319) at 1/1000 dilution

      Lane 1 : C2C12 cell lysate
      Lane 2 : A431 cell lysate
      Lane 3 : NIH 3T3 cell lysate
      Lane 4 : Neuro 2a cell lysate
      Lane 5 : L6 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : Goat anti-Rabbit HRP at 1/2000 dilution

      Predicted band size: 68 kDa

    • Immunohistochemical analysis of Paraffin Embedded Human stomach tissue labelling COX1/Cyclooxygenase 1 with ab133319 at 1/50 dilution.
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References

    This product has been referenced in:

    • Périco LL  et al. Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats. World J Gastroenterol 24:4369-4383 (2018). Read more (PubMed: 30344421) »
    • Kitanaka T  et al. JNK activation is essential for activation of MEK/ERK signaling in IL-1ß-induced COX-2 expression in synovial fibroblasts. Sci Rep 7:39914 (2017). WB, RT-PCR ; Cat . Read more (PubMed: 28054591) »
    See all 4 Publications for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab133319.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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