Key features and details
- Rabbit polyclonal to COX10
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-COX10 antibody
See all COX10 primary antibodies
DescriptionRabbit polyclonal to COX10
SpecificityThis antibody detects endogenous levels of total COX10 protein.
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Recombinant fragment corresponding to Human COX10 (internal sequence).
Database link: Q12887
- Human renal cancer tissue.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab197392 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/50 - 1/200.|
FunctionConverts protoheme IX and farnesyl diphosphate to heme O.
Involvement in diseaseDefects in COX10 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
Defects in COX10 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.
Sequence similaritiesBelongs to the ubiA prenyltransferase family.
Cellular localizationMitochondrion membrane.
- Information by UniProt
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- COX10 antibody
ab197392 has not yet been referenced specifically in any publications.