Overview

  • Product name

  • Description

    Rabbit polyclonal to COX10
  • Host species

    Rabbit
  • Specificity

    This antibody detects endogenous levels of total COX10 protein.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human COX10 (internal sequence).
    Database link: Q12887

  • Positive control

    • Human renal cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab197392 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.

Target

  • Function

    Converts protoheme IX and farnesyl diphosphate to heme O.
  • Involvement in disease

    Defects in COX10 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
    Defects in COX10 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.
  • Sequence similarities

    Belongs to the ubiA prenyltransferase family.
  • Cellular localization

    Mitochondrion membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 2410004F01Rik antibody
    • AU042636 antibody
    • COX10 antibody
    • COX10_HUMAN antibody
    • Cytochrome c oxidase assembly protein antibody
    • Cytochrome c oxidase subunit X antibody
    • Heme A farnesyltransferase antibody
    • Heme O synthase antibody
    • OTTMUSP00000006085 antibody
    • Protoheme IX farnesyltransferase, mitochondrial antibody
    • Protoheme IX farnesyltransferase, mitochondrial precursor antibody
    • RP23-78H18.1 antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed paraffin embedded human renal cancer tissue labeling COX10 with ab197392 at a 1/100 dilution.

References

ab197392 has not yet been referenced specifically in any publications.

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