Overview

  • Product name

  • Description

    Rabbit polyclonal to COX10
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Cow, Pig, Rhesus monkey
  • Immunogen

    Recombinant fragment within Human COX10 (internal sequence). The exact sequence is proprietary.
    Database link: Q12887

  • Positive control

    • WB: U-87 MG, SK-N-SH, IMR32 and SK-N-AS whole cell extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab228734 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 49 kDa.

Target

  • Function

    Converts protoheme IX and farnesyl diphosphate to heme O.
  • Involvement in disease

    Defects in COX10 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
    Defects in COX10 are a cause of Leigh syndrome (LS) [MIM:256000]. LS is a severe neurological disorder characterized by bilaterally symmetrical necrotic lesions in subcortical brain regions.
  • Sequence similarities

    Belongs to the ubiA prenyltransferase family.
  • Cellular localization

    Mitochondrion membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 2410004F01Rik antibody
    • AU042636 antibody
    • COX10 antibody
    • COX10_HUMAN antibody
    • Cytochrome c oxidase assembly protein antibody
    • Cytochrome c oxidase subunit X antibody
    • Heme A farnesyltransferase antibody
    • Heme O synthase antibody
    • OTTMUSP00000006085 antibody
    • Protoheme IX farnesyltransferase, mitochondrial antibody
    • Protoheme IX farnesyltransferase, mitochondrial precursor antibody
    • RP23-78H18.1 antibody
    see all

Images

  • All lanes : Anti-COX10 antibody (ab228734) at 1/1000 dilution

    Lane 1 : U-87 MG (human glioblastoma-astrocytoma epithelial cell line) whole cell extract
    Lane 2 : SK-N-SH (human neuroblastoma cell line) whole cell extract
    Lane 3 : IMR32 whole cell extract
    Lane 4 : SK-N-AS whole cell extract

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 49 kDa



    10% SDS-PAGE gel.

References

ab228734 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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