Recombinant Anti-COX2 / Cyclooxygenase 2 antibody [EPR8588] (ab151571)
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR8588] to COX2 / Cyclooxygenase 2
- Suitable for: WB
- Reacts with: Human
Overview
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Product name
Anti-COX2 / Cyclooxygenase 2 antibody [EPR8588]
See all COX2 / Cyclooxygenase 2 primary antibodies -
Description
Rabbit monoclonal [EPR8588] to COX2 / Cyclooxygenase 2 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details
Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment corresponding to Human COX2/ Cyclooxygenase 2 aa 500-600.
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Positive control
- A549 cell lysate.
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General notes
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at -20ºC. -
Storage buffer
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading...
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Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
EPR8588 -
Isotype
IgG -
Research areas
Associated products
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab151571 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/1000 - 1/10000. Predicted molecular weight: 69 kDa.
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Notes |
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WB
1/1000 - 1/10000. Predicted molecular weight: 69 kDa. |
Target
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Function
Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity. -
Pathway
Lipid metabolism; prostaglandin biosynthesis. -
Sequence similarities
Belongs to the prostaglandin G/H synthase family.
Contains 1 EGF-like domain. -
Post-translational
modificationsS-nitrosylation by NOS2 (iNOS) activates enzme activity. S-nitrosylation may take place on different Cys residues in addition to Cys-561. -
Cellular localization
Microsome membrane. Endoplasmic reticulum membrane. - Information by UniProt
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Database links
- Entrez Gene: 5743 Human
- Omim: 600262 Human
- SwissProt: P35354 Human
- Unigene: 196384 Human
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Alternative names
- COX 2 antibody
- COX-2 antibody
- COX2 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab151571 has been referenced in 1 publication.
- Zheng BY et al. HBx promotes the proliferative ability of HL-7702 cells via the COX-2/Wnt/ß-catenin pathway. Mol Med Rep 17:8432-8438 (2018). PubMed: 29693167