Overview

  • Product name

    Anti-COX6B1 antibody [EPR7646]
    See all COX6B1 primary antibodies
  • Description

    Rabbit monoclonal [EPR7646] to COX6B1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IPmore details
    Unsuitable for: Flow Cyt,ICC/IF or IHC-P
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human COX6B1 aa 1-100. The exact sequence is proprietary.

  • Positive control

    • HepG2 and Caco 2 cell lysates.
  • General notes

     

     

     This product was previously labelled as Cytochrome C Oxidase subunit VIb

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Applications

Our Abpromise guarantee covers the use of ab137089 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 10 kDa.
IP 1/100 - 1/500.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
  • Target

    • Function

      Connects the two COX monomers into the physiological dimeric form.
    • Involvement in disease

      Defects in COX6B1 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
    • Sequence similarities

      Belongs to the cytochrome c oxidase subunit 6B family.
    • Cellular localization

      Mitochondrion intermembrane space.
    • Information by UniProt
    • Database links

    • Alternative names

      • COX 6B antibody
      • COX VIb 1 antibody
      • COX VIb-1 antibody
      • COX6B antibody
      • COX6B1 antibody
      • COXG antibody
      • COXVIb1 antibody
      • CX6B1_HUMAN antibody
      • Cytochrome c oxidase subunit 6B1 antibody
      • Cytochrome c oxidase subunit VIb antibody
      • Cytochrome c oxidase subunit VIb isoform 1 antibody
      • cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) antibody
      • Cytochrome c oxidase subunit Vib polypeptide 1 antibody
      see all

    Images

    • All lanes : Anti-COX6B1 antibody [EPR7646] (ab137089) at 1/1000 dilution

      Lane 1 : Caco 2 cell lysates
      Lane 2 : HepG2 cell lysates

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 10 kDa

    References

    This product has been referenced in:

    • Kim SE  et al. Upregulation of cytochrome c oxidase subunit 6b1 (Cox6b1) and formation of mitochondrial supercomplexes: implication of Cox6b1 in the effect of calorie restriction. Age (Dordr) 37:9787 (2015). Read more (PubMed: 25929654) »
    See 1 Publication for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab137089.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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