CP 154526 hydrochloride, non-peptide CRF1 receptor antagonist (ab141429)

Overview

  • Product name

    CP 154526 hydrochloride, non-peptide CRF1 receptor antagonist
  • Description

    Potent, selective, non-peptide CRF1 receptor antagonist
  • Biological description

    Potent, selective, non-peptide corticotropin factor receptor-1 antagonist (Ki = 10 nM). Blood-brain barrier permeable. Neuroprotective and antistress agent. Active in vivo and in vitro.
  • Purity

    > 99%
  • CAS Number

    257639-98-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride
  • Molecular weight

    400.99
  • Molecular formula

    C23H32N4.HCl
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 50 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.CCN(CCCC)c1nc(C)nc2c1c(C)cn2c3c(C)cc(C)cc3C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Lowery EG  et al. The CRF-1 receptor antagonist, CP-154,526, attenuates stress-induced increases in ethanol consumption by BALB/cJ mice. Alcohol Clin Exp Res 32:240-8 (2008). Read more (PubMed: 18162074) »
  • Seymour PA  et al. The pharmacology of CP-154,526, a non-peptide antagonist of the CRH1 receptor: a review. CNS Drug Rev 9:57-96 (2003). Read more (PubMed: 12595912) »
  • Schulz DW  et al. CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors. Proc Natl Acad Sci U S A 93:10477-82 (1996). Read more (PubMed: 8816826) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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