Overview

  • Product name

    CP-31398 dihydrochloride, p53 stabilizing agent
  • Description

    p53 stabilizing agent
  • Biological description

    p53 stabilizing agent. Promotes active conformation of p53 and restores wild-type conformation of mutant p53 in vitro. Able to induce cell cycle arrest and apoptosis. Chemopreventative activity in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    259199-65-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Rao CV  et al. Inhibition of azoxymethane-induced colorectal cancer by CP-31398, a TP53 modulator, alone or in combination with low doses of celecoxib in male F344 rats. Cancer Res 69:8175-82 (2009). Read more (PubMed: 19826045) »
  • Wang W  et al. Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding. Mol Cell Biol 23:2171-81 (2003). Read more (PubMed: 12612087) »
  • Foster BA  et al. Pharmacological rescue of mutant p53 conformation and function. Science 286:2507-10 (1999). Read more (PubMed: 10617466) »
  • Takimoto R  et al. The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein. Cancer Biol Ther 1:47-55 (0). Read more (PubMed: 12174820) »
  • Wang W  et al. Restoring p53-dependent tumor suppression. Cancer Biol Ther 2:S55-63 (0). Read more (PubMed: 14508081) »

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