CP 339818 hydrochloride, KV1.3 and KV1.4 channel blocker (ab145535)

Overview

  • Product name

    CP 339818 hydrochloride, KV1.3 and KV1.4 channel blocker
  • Description

    Potent, selective, competitive KV1.3 and KV1.4 channel blocker
  • Biological description

    Potent, selective, competitive KV1.3 and KV1.4 channel blocker (IC50 values are 200 and 300 nM for KV1.3 and respectively). Binds preferentially to the C-type inactivated state. Suppresses T cell activation.
  • Purity

    > 98%
  • CAS Number

    185855-91-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Lee YT  et al. Novel pharmacological activity of loperamide and CP-339,818 on human HCN channels characterized with an automated electrophysiology assay. Eur J Pharmacol 581:97-104 (2008). Read more (PubMed: 18162181) »
  • Jäger H  et al. Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated states. J Physiol 506 ( Pt 2):291-301 (1998). Read more (PubMed: 9490854) »
  • Nguyen A  et al. Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. Mol Pharmacol 50:1672-9 (1996). Read more (PubMed: 8967992) »

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