Overview

  • Product name
  • Description
    Goat polyclonal to CP110
  • Host species
    Goat
  • Specificity
    ab169828 is expected to recognize both reported isoforms (NP_001185951.1; NP_055526.3).
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to N terminal amino acids 8-19 of Human CP110 (NP_001185951.1, NP_055526.3).

  • Positive control
    • Human testis lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab169828 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 110 kDa (predicted molecular weight: 113 kDa). Additional bands of unknown identity were also consistently observed at 65kDa and 37kDa. These bands were successfully blocked by incubation with the immunizing peptide.

Target

  • Function
    Necessary for centrosome duplication at different stages of procentriole formation. Collaborates with CEP97, being involved in the suppression of a cilia assembly program. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.
  • Tissue specificity
    Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.
  • Post-translational
    modifications
    Phosphorylated by CDKs.
    Ubiquitinated by the SCF(Cyclin F) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication.
  • Cellular localization
    Cytoplasm > cytoskeleton > centrosome > centriole. Recruited early and then associates with the growing distal tips.
  • Information by UniProt
  • Database links
  • Alternative names
    • 110 kDa centrosomal protein antibody
    • CCP110 antibody
    • Centriolar coiled coil protein 110kDa antibody
    • Centrosomal protein 110 kDa antibody
    • Centrosomal protein CP110 antibody
    • Centrosomal protein of 110 kDa antibody
    • Cep110 antibody
    • CP110 antibody
    • CP110_HUMAN antibody
    • DKFZp781G1416 antibody
    • FAN antibody
    • KIAA0419 antibody
    see all

References

ab169828 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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