Overview

  • Product name

  • Description

    Rabbit polyclonal to CPE
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant full length protein corresponding to Human CPE.
    Database link: P16870

  • Positive control

    • Extracts of A549, MCF7, mouse brain and mouse kidney cell lines.
  • General notes

     This product was previously labelled as Carboxypeptidase H

     

Properties

Applications

Our Abpromise guarantee covers the use of ab186724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration.
WB 1/500 - 1/2000. Predicted molecular weight: 53 kDa.
IHC-P 1/50 - 1/200.

Target

  • Function

    Removes residual C-terminal Arg or Lys remaining after initial endoprotease cleavage during prohormone processing. Processes proinsulin.
  • Tissue specificity

    Isoform 2, but not isoform 1, is overexpressed in hepatocellular carcinoma (at protein level), as well as in other tumors, including pheochromocytomas and paragangliomas.
  • Sequence similarities

    Belongs to the peptidase M14 family.
  • Cellular localization

    Nucleus and Secreted. Secretory granules of pancreatic islets, adrenal gland, pituitary and brain.
  • Information by UniProt
  • Database links

  • Alternative names

    • Carboxypeptidase E antibody
    • Carboxypeptidase H antibody
    • Carboxypeptidase H precursor antibody
    • CarboxypeptidaseE antibody
    • CarboxypeptidaseH antibody
    • CBPE_HUMAN antibody
    • Cobalt stimulated chromaffin granule carboxypeptidase antibody
    • CPE antibody
    • Cph 1 antibody
    • CPH antibody
    • Enkephalin convertase antibody
    • Entephalin convertase antibody
    • Insulin granule associated carboxypeptidase antibody
    • Prohormone processing carboxypeptidase antibody
    • Prohormone-processing carboxypeptidase antibody
    see all

Images

  • Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab186724. Blue DAPI for nuclear staining.
  • All lanes : Anti-CPE antibody (ab186724) at 1/500 dilution

    Lane 1 : Extract of A549 cell line.
    Lane 2 : Extract of MCF7 cell line.
    Lane 3 : Extract of mouse brain cell line.
    Lane 4 : Extract of mouse kidney cell line.

    Predicted band size: 53 kDa

References

ab186724 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab186724.
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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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