CPI-613, alpha-ketoglutarate dehydrogenase inhibitor (ab143285)

Overview

  • Product name

    CPI-613, alpha-ketoglutarate dehydrogenase inhibitor
  • Description

    Tumor-selective α-ketoglutarate dehydrogenase inhibitor. Antitumor agent.
  • Biological description

    Tumor-selective α-ketoglutarate dehydrogenase inhibitor. Antitumor agent. Induces apoptotic and non-apoptotic cell death in tumor cell lines. Induces mitochondrial redox signal and loss of cell membrane potential. Lipoate analog. Shows potent antitumor effects in vivo.
  • Purity

    > 98%
  • CAS Number

    95809-78-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6,8-Bis(benzylsulfanyl)octanoic acid
  • Molecular weight

    388.59
  • Molecular formula

    C22H28O2S2
  • PubChem identifier

    24770514
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    S(CCC(SCC1=CC=CC=C1)CCCCC(O)=O)CC2=CC=CC=C2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Stuart SD  et al. A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process. Cancer Metab 2:4 (2014). Read more (PubMed: 24612826) »
  • Lee KC  et al. Formation and anti-tumor activity of uncommon in vitro and in vivo metabolites of CPI-613, a novel anti-tumor compound that selectively alters tumor energy metabolism. Drug Metab Lett 5:163-82 (2011). Read more (PubMed: 21722089) »
  • Zachar Z  et al. Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo. J Mol Med (Berl) 89:1137-48 (2011). Read more (PubMed: 21769686) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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