Overview

  • Product name

  • Description

    Rabbit polyclonal to CPN1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human CPN1 (internal sequence). The exact sequence is proprietary.
    Database link: P15169

  • Positive control

    • WB: HepG2 grown in conditioned medium whole cell extract.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 1% BSA, 20% Glycerol, PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab226976 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 52 kDa.

Target

  • Function

    Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
  • Tissue specificity

    Synthesized in the liver and secreted in plasma.
  • Involvement in disease

    Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND) [MIM:212070]. Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder.
  • Sequence similarities

    Belongs to the peptidase M14 family.
  • Cellular localization

    Secreted > extracellular space.
  • Information by UniProt
  • Database links

  • Alternative names

    • ACBP antibody
    • Anaphylatoxin inactivator antibody
    • Arginine carboxypeptidase antibody
    • Carboxypeptidase N catalytic chain antibody
    • Carboxypeptidase N polypeptide 1 50 kD antibody
    • Carboxypeptidase N polypeptide 1 antibody
    • Carboxypeptidase N small subunit antibody
    • Carboxypeptidase N subunit 1 antibody
    • CBPN_HUMAN antibody
    • CPN antibody
    • CPN1 antibody
    • Kininase 1 antibody
    • Kininase-1 antibody
    • Kininase1 antibody
    • Lysine carboxypeptidase antibody
    • Plasma carboxypeptidase B antibody
    • SCPN antibody
    • Serum carboxypeptidase N antibody
    see all

Images

  • Anti-CPN1 antibody (ab226976) at 1/500 dilution + HepG2 (human liver hepatocellular carcinoma cell line) grown in conditioned medium, whole cell extract at 30 µg

    Predicted band size: 52 kDa



    10% SDS-PAGE gel.

References

ab226976 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab226976.
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