Overview

  • Product name

    Anti-CPTP antibody - N-terminal
  • Description

    Rabbit polyclonal to CPTP - N-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human CPTP aa 1-28 (N terminal).
    Sequence:

    MDDSETGFNLKVVLVSFKQCLDEKEEVL


    Database link: Q5TA50

  • Positive control

    • Human small intestine tissue.
  • General notes

    Previously labelled as GLTPD1.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.2
    Preservative: 0.02% Sodium azide
    Constituents: 59% PBS, 40% Glycerol
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab185574 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Mediates the intracellular transfer of ceramide-1-phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide.
  • Tissue specificity

    Ubiquitous. Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
  • Sequence similarities

    Belongs to the GLTP family.
  • Cellular localization

    Cytoplasm > cytosol. Golgi apparatus > trans-Golgi network membrane. Cell membrane. Endosome membrane. Nucleus outer membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Ceramide-1-phosphate transfer protein antibody
    • CPTP antibody
    • CPTP_HUMAN antibody
    • gltpd1 antibody
    • Glycolipid transfer protein domain-containing protein 1 antibody
    see all

Images

  • Immunohistochemistry of paraffin-embedded Human small intestine tissue labeling CPTP using ab185574 at 1/20.

References

ab185574 has not yet been referenced specifically in any publications.

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