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Anti-CRALBP antibody [B2] - BSA and Azide free (ab264522)

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Western blot - Anti-CRALBP antibody [B2] - BSA and Azide free (ab264522)

    Key features and details

    • Mouse monoclonal [B2] to CRALBP - BSA and Azide free
    • Suitable for: WB
    • Reacts with: Rat
    • Isotype: IgG1

    You may also be interested in

    Protein
    Product image
    Recombinant Human CRALBP protein (denatured) (ab177594)
    Secondary
    Product image
    Goat Anti-Mouse IgG H&L (HRP) (ab205719)

    View more associated products

    Overview

    • Product name

      Anti-CRALBP antibody [B2] - BSA and Azide free
      See all CRALBP primary antibodies
    • Description

      Mouse monoclonal [B2] to CRALBP - BSA and Azide free
    • Host species

      Mouse
    • Tested Applications & Species

      Application Species
      WB
      Rat
      See all applications and species data
    • Immunogen

      Recombinant full length protein corresponding to Human CRALBP.

    • Positive control

      • This antibody gave a positive signal in the following tissue lysates: rat eye; rat retina.
    • General notes

      ab264522 is the carrier-free version of ab15051.

      This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C. Do Not Freeze.
    • Storage buffer

      Constituent: PBS
    • Carrier free

      Yes
    • Concentration information loading...
    • Purity

      IgG fraction
    • Clonality

      Monoclonal
    • Clone number

      B2
    • Isotype

      IgG1
    • Light chain type

      kappa
    • Research areas

      • Neuroscience
      • Sensory System
      • Visual system
      • Neuroscience
      • Neurotransmitter
      • Transporters
      • Other Transporters

    Associated products

    • Alternative Versions

      • Anti-CRALBP antibody [B2] (ab15051)
      • HRP Anti-CRALBP antibody [B2] (ab199992)
    • Compatible Secondaries

      • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
      • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
    • Isotype control

      • Mouse IgG1, kappa monoclonal [15-6E10A7] - Isotype Control (ab170190)
    • Recombinant Protein

      • Recombinant Human CRALBP protein (denatured) (ab177594)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab264522 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    WB
    Rat
    All applications
    Mouse
    Cow
    Human
    Monkey
    Application Abreviews Notes
    WB
    Use a concentration of 1 µg/ml. Detects a band of approximately 35 kDa (predicted molecular weight: 36 kDa).
    Notes
    WB
    Use a concentration of 1 µg/ml. Detects a band of approximately 35 kDa (predicted molecular weight: 36 kDa).

    Target

    • Function

      Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'.
    • Tissue specificity

      Retina and pineal gland. Not present in photoreceptor cells but is expressed abundantly in the adjacent retinal pigment epithelium (RPE) and in the Mueller glial cells of the retina.
    • Involvement in disease

      Defects in RLBP1 are a cause of retinitis pigmentosa autosomal recessive (ARRP) [MIM:268000]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
      Defects in RLBP1 are the cause of Bothnia retinal dystrophy (BRD) [MIM:607475]; also known as Vasterbotten dystrophy. Affected individuals show night blindness from early childhood with features consistent with retinitis punctata albescens and macular degeneration.
      Defects in RLBP1 are the cause of rod-cone dystrophy Newfoundland (NFRCD) [MIM:607476]. NFRCD is a retinal dystrophy reminiscent of retinitis punctata albescens but with a substantially lower age at onset and more-rapid and distinctive progression. Rod-cone dystrophies results from initial loss of rod photoreceptors, later followed by cone photoreceptors loss.
      Defects in RLBP1 are a cause of fundus albipunctatus (FA) [MIM:136880]. FA is a rare form of stationary night blindness characterized by a delay in the regeneration of cone and rod photopigments.
    • Sequence similarities

      Contains 1 CRAL-TRIO domain.
    • Cellular localization

      Cytoplasm.
    • Target information above from: UniProt accession P12271 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 282038 Cow
      • Entrez Gene: 6017 Human
      • Entrez Gene: 19771 Mouse
      • Entrez Gene: 293049 Rat
      • Omim: 180090 Human
      • SwissProt: P10123 Cow
      • SwissProt: P12271 Human
      • SwissProt: Q9Z275 Mouse
      • Unigene: 1933 Human
      • Unigene: 41653 Mouse
      see all
    • Alternative names

      • Cellular retinaldehyde binding protein 1 antibody
      • Cellular retinaldehyde binding protein antibody
      • Cellular retinaldehyde-binding protein antibody
      • MGC3663 antibody
      • Retinaldehyde binding protein 1 antibody
      • Retinaldehyde-binding protein 1 antibody
      • RLBP 1 antibody
      • RLBP1 antibody
      • RLBP1_HUMAN antibody
      see all

    Images

    • Western blot - Anti-CRALBP antibody [B2] - BSA and Azide free (ab264522)
      Western blot - Anti-CRALBP antibody [B2] - BSA and Azide free (ab264522)
      All lanes : Anti-CRALBP antibody [B2] (ab15051) at 1 µg/ml

      Lane 1 : ab4035, Rat eye tissue lysate, 10 ug
      Lane 2 : Rat retina tissue lysate, 10 ug

      Secondary
      All lanes : Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

      Developed using the ECL technique.

      Performed under reducing conditions.

      Predicted band size: 36 kDa


      Exposure time: 30 seconds


      This data was developed using the same antibody clone in a different buffer formulation containing PBS, L-Arginine and sodium azide (ab15051)

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab264522? Please let us know so that we can cite the reference in this datasheet.

    ab264522 has not yet been referenced specifically in any publications.

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