CRANAD-2, Near-infrared Amyloid-beta fluorescent probe (ab141775)

Overview

  • Product name
    CRANAD-2, Near-infrared Amyloid-beta fluorescent probe
  • Description
    Near-infrared Amyloid-β fluorescent probe
  • Alternative names
    • CRANAD 2
  • Biological description

    Near-infrared (NIR) Amyloid-β fluorescent probe. Upon interacting with Amyloid-β aggregates displays a 70-fold increase in fluorescence intensity accompanied by a 90 nm blue shift from 805 to 715 nm. Demonstrates high affinity for amyloid-β aggregates (Kd = 38 nM). Detects amyloid-β in vitro and in vivo. Blood-brain barrier permeable. Learn more

  • Purity
    > 98%
  • CAS Number
    1193447-34-5
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    (T-4)-[(1E,6E)-1,7-Bis[4-(dimethylamino)phenyl]-1,6-heptadiene-3,5-
    dionato-kO3,kO5]difluoroboron
  • Molecular weight
    410.27
  • Molecular formula
    C23H25BF2N2O2
  • Storage instructions
    Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.
  • Solubility overview
    Soluble in DMSO to 5 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    CN(C)c1ccc(cc1)/C=C/C3=O[BH2+3]([F-])([F-])O=C(/C=C/c2ccc(cc2)N(C)C)C3
  • Source

    Synthetic

References

This product has been referenced in:
  • Tong H  et al. Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer?s disease. Acta Pharm Sin B 5:25-33 (2015). Read more (PubMed: 26579421) »
  • Ran C  et al. Non-conjugated small molecule FRET for differentiating monomers from higher molecular weight amyloid beta species. PLoS One 6:e19362 (2011). Read more (PubMed: 21559413) »
  • Ran C  et al. Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. J Am Chem Soc 131:15257-61 (2009). Read more (PubMed: 19807070) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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