Near-infrared (NIR) Amyloid-β fluorescent probe. Demonstrates different fluorescence response towards soluble and insoluble Aβ species. Significant fluorescence intensity increase (91.9-fold for Aβ40, 113.6-fold for Aβ42) and high affinity (Kd values are 105.8 nM and 45.8 nM for Aβ40 and Aβ42 respectively) for Aβ monomers observed. Detects soluble Aβ species in transgenic APP/PS1 mice at the age of 4 months. Learn more
Shipped at 4°C. Store at -20°C long term. Store under desiccating conditions.
Soluble in DMSO to 10 mM
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
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Tong H et al. Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer?s disease. Acta Pharm Sin B5:25-33 (2015).
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Zhang X et al. Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's disease. J Am Chem Soc135:16397-409 (2013).
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