Overview

  • Product name
  • Description
    Rabbit polyclonal to CRB3
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human CRB3 aa 66-95 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary. (NP_631900.1, NP_777377.1)
    Database link: Q9BUF7

  • Positive control
    • Mouse spleen tissue lysate

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab173169 is purified through a protein A column, followed by peptide affinity purification
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab173169 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 13 kDa.

Target

  • Function
    Involved in the establishment of cell polarity in mammalian epithelial cells. Regulates the morphogenesis of tight junctions.
  • Tissue specificity
    Preferentially expressed in epithelial tissues. Expressed at high levels in lung, kidney, retina, colon and mammary glands. Expressed at moderate levels in liver, spleen, pancreas, placenta and prostate.
  • Domain
    The PDZ-binding motif is involved in the interactions with PARD6A and MPP5.
  • Cellular localization
    Apical cell membrane. Cell junction > tight junction. Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • CRB3 antibody
    • CRUM3_HUMAN antibody
    • crumbs homolog 3 (Drosophila) antibody
    • Crumbs protein homolog 3 antibody
    • crumbs, Drosophila, homolog of, 3 antibody
    • PRO1158 antibody
    • protein crumbs homolog 3 antibody
    • UNQ588 antibody
    see all

Images

  • Anti-CRB3 antibody (ab173169) at 1/100 dilution + mouse spleen tissue lysate at 35 µg

    Predicted band size: 13 kDa

References

This product has been referenced in:
  • Gao Y  et al. Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cells. Sci Rep 6:28589 (2016). Read more (PubMed: 27358069) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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