Description

Specifications

Our Abpromise guarantee covers the use of ab204856 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

    Functional Studies

  • Form

    Lyophilised
  • Additional notes

    ab204856 (CREB peptide) can be utilized as a substrate for the following active protein kinases:

     

    ab190396 (Active human KSR1 protein fragment)
    ab185259 (Active human KSR2 protein fragment)
    ab56268 (Active human cAMP Protein Kinase Catalytic subunit full length protein)
    ab60837 (Active human PKA beta (catalytic subunit) full length protein)
    ab60838 (Active human PKA gamma (catalytic subunit) full length protein)
    ab60839 (Active X. laevis PKC alpha full length protein)
    ab55672 (Active human PKC alpha full length protein)
    ab60841 (Active human PKC beta 2 full length protein)
    ab60844 (Active human PKC delta full length protein)
    ab60850 (Active human PKC iota full length protein)
    ab89860 (Active human PKN2 full length protein)
    ab60873 (Active human PKC mu full length protein)
    ab60874 (Active human PKC nu full length protein)
    ab60848 (Active human PKC zeta full length protein)
    ab60875 (Active human Protein Kinase D2 full length protein)
    ab139624 (Active human STK19 full length protein)

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Dilute peptide in 20mM Tris-HCl, pH 7.5 solution to a final concentration of 1 mg/ml. For optimal storage, aliquot diluted product into smaller quantities and store at recommended temperature.

General Info

  • Alternative names

    • Active transcription factor CREB
    • cAMP response element binding protein
    • cAMP response element binding protein 1
    • cAMP responsive element binding protein 1
    • cAMP-responsive element-binding protein 1
    • CREB
    • CREB-1
    • CREB1
    • CREB1_HUMAN
    • Cyclic AMP-responsive element-binding protein 1
    • MGC9284
    • OTTHUMP00000163864
    • OTTHUMP00000163865
    • OTTHUMP00000206660
    • OTTHUMP00000206662
    • OTTHUMP00000206667
    • Transactivator protein
    see all
  • Function

    This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity.
  • Involvement in disease

    Defects in CREB1 may be a cause of angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=A chromosomal aberration involving CREB1 is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type.
  • Sequence similarities

    Belongs to the bZIP family.
    Contains 1 bZIP domain.
    Contains 1 KID (kinase-inducible) domain.
  • Post-translational
    modifications

    Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
    Sumoylated by SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization.
  • Cellular localization

    Nucleus.
  • Information by UniProt

References

ab204856 has not yet been referenced specifically in any publications.

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