Key features and details
- Goat polyclonal to CREB3L1/OASIS
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-CREB3L1/OASIS antibody
See all CREB3L1/OASIS primary antibodies
DescriptionGoat polyclonal to CREB3L1/OASIS
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
- Human Liver and Human Skeletal Muscle tissue; A549 cell lysate
Previously labelled as CREB3L1.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab112021 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 - 3 µg/ml. Predicted molecular weight: 57 kDa.|
|IHC-P||Use a concentration of 3.75 µg/ml.|
FunctionTranscription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE.
Tissue specificityUbiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain.
Sequence similaritiesBelongs to the bZIP family. ATF subfamily.
Contains 1 bZIP domain.
modificationsControlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is performed sequentially by site-1 and site-2 proteases (PS1 and PS2) and is triggered by translocation to the Golgi apparatus.
Cellular localizationEndoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
- Information by UniProt
- BBF-2 homolog antibody
- CAMP responsive element binding protein 3 like 1 antibody
- cAMP-responsive element-binding protein 3-like protein 1 antibody
Immunohistochemical analysis of CREB3L1/OASIS expression in formalin-fixed, paraffin-embedded Human liver using ab112021 at 3.75 µg/ml.
Immunohistochemical analysis of CREB3L1/OASIS expression in formalin-fixed, paraffin-embedded Human skeletal muscle using ab112021 at 3.75 µg/ml.
Anti-CREB3L1/OASIS antibody (ab112021) at 3 µg/ml + A549 cell lysate
Predicted band size: 57 kDa
ab112021 has not yet been referenced specifically in any publications.