Anti-CREB3L1/OASIS antibody (ab137565)
Key features and details
- Rabbit polyclonal to CREB3L1/OASIS
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-CREB3L1/OASIS antibody -
Description
Rabbit polyclonal to CREB3L1/OASIS -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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Positive control
- 293T, A431, H1299, HeLa S3, HepG2, Molt 4, Raji whole cell lysates
Paraformaldehyde fixed HCT116
- 293T, A431, H1299, HeLa S3, HepG2, Molt 4, Raji whole cell lysates
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General notes
Keep as concentrated solution.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 89.99% PBS, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab137565 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
1/500 - 1/3000. Predicted molecular weight: 57 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 57 kDa. |
Target
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Function
Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE. -
Tissue specificity
Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain. -
Sequence similarities
Belongs to the bZIP family. ATF subfamily.
Contains 1 bZIP domain. -
Post-translational
modificationsControlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is performed sequentially by site-1 and site-2 proteases (PS1 and PS2) and is triggered by translocation to the Golgi apparatus. -
Cellular localization
Endoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. - Information by UniProt
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Database links
- Entrez Gene: 90993 Human
- SwissProt: Q96BA8 Human
- Unigene: 405961 Human
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Alternative names
- BBF-2 homolog antibody
- CAMP responsive element binding protein 3 like 1 antibody
- cAMP-responsive element-binding protein 3-like protein 1 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab137565 has not yet been referenced specifically in any publications.