Overview

  • Product name

    Anti-CREB3L1/OASIS antibody
    See all CREB3L1/OASIS primary antibodies
  • Description

    Rabbit polyclonal to CREB3L1/OASIS
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human CREB3L1/OASIS aa 447-519 (C terminal).

  • Positive control

    • 293T, A431, H1299, HeLa S3, HepG2, Molt 4, Raji whole cell lysates
      Paraformaldehyde fixed HCT116
  • General notes

    Keep as concentrated solution.

    Previously labelled as CREB3L1. 

Properties

Applications

Our Abpromise guarantee covers the use of ab137565 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 57 kDa.

Target

  • Function

    Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE.
  • Tissue specificity

    Ubiquitously expressed with high levels in pancreas and prostate. Expressed at relatively lower levels in brain.
  • Sequence similarities

    Belongs to the bZIP family. ATF subfamily.
    Contains 1 bZIP domain.
  • Post-translational
    modifications

    Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is performed sequentially by site-1 and site-2 proteases (PS1 and PS2) and is triggered by translocation to the Golgi apparatus.
  • Cellular localization

    Endoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • BBF-2 homolog antibody
    • CAMP responsive element binding protein 3 like 1 antibody
    • cAMP-responsive element-binding protein 3-like protein 1 antibody
    • CR3L1_HUMAN antibody
    • Creb3l1 antibody
    • Cyclic AMP responsive element binding protein 3 like protein 1 antibody
    • OASIS antibody
    • Old astrocyte specifically-induced substance antibody
    • Processed cyclic AMP-responsive element-binding protein 3-like protein 1 antibody
    see all

Images

  • All lanes : Anti-CREB3L1/OASIS antibody (ab137565) at 1/1500 dilution

    Lane 1 : HepG2 whole cell lysate
    Lane 2 : Molt 4 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 57 kDa



    12% SDS PAGE

References

ab137565 has not yet been referenced specifically in any publications.

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