Overview

  • Product name

  • Description

    Rabbit polyclonal to CREB3L3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 125-214 of Human CREB3L3 (UniProt: Q68CJ9-1).

  • Positive control

    • Human liver tissue; U2 OS cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab150865 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml. Use PFA/Triton X-100 Fixation/Permeabilization.

Target

  • Relevance

    Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE. Seems to function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression.
  • Cellular localization

    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Nucleus.
  • Database links

  • Alternative names

    • cAMP responsive element binding protein 3 like 3 antibody
    • cAMP responsive element-binding protein 3 like protein 3 antibody
    • CREB H antibody
    • CREB/ATF family transcription factor antibody
    • CREBH antibody
    • Cyclic AMP responsive element binding protein 3 like protein 3 antibody
    • HYST1481 antibody
    • MGC126553 antibody
    • MGC126557 antibody
    • Transcription factor CREB H antibody
    see all

Images

  • Immunohistochemical analysis of Paraffin-embedded Human liver tissue labeling CREB3L3 with ab150865 at 1/200 dilution.
  • Immunofluorescent analysis of PFA/Triton X-100 fixed/permeabilized U2 OS cells labeling CREB3L3 with ab150865 at 4µg/ml.

References

This product has been referenced in:

  • Jang M  et al. Study of melatonin-mediated effects on various hepatic inflammatory responses stimulated by IL-6 in a new HepG2-on-a-chip platform. Biomed Microdevices 20:54 (2018). Read more (PubMed: 29946898) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab150865.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up