Overview

  • Product name

  • Description

    Rabbit polyclonal to CRELD1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Rat, Horse, Guinea pig, Cow, Cat, Dog, Human
  • Immunogen

    Synthetic peptide, corresponding to a region within internal sequence amino acids 191-240 of Mouse CRELD1 (NP_598691).

  • Positive control

    • Mouse lung lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab140346 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 46 kDa.

Target

  • Tissue specificity

    Highly expressed in fetal lung, liver, kidney, adult heart, brain and skeletal muscle. Weakly expressed in placenta, fetal brain, and adult lung, liver, kidney and pancreas.
  • Involvement in disease

    Defects in CRELD1 may be the cause of susceptibility to atrioventricular septal defect type 2 (AVSD2) [MIM:606217]. AVSD is a spectrum of cardiac malformations that result in a persistent common atrioventricular canal. The complete form of AVSD involves underdevelopment of the lower part of the atrial septum and the upper part of the ventricular septum. A less severe form, known as partial AVSD or ostium primum atrial septal defect has a deficiency of the atrial septum. Complete AVSD are clinically apparent at birth, whereas less severe forms, such as an isolated cleft mitral valve or small defects of the atrial or ventricular septa may go undetected.
  • Sequence similarities

    Belongs to the CRELD family.
    Contains 2 EGF-like domains.
    Contains 2 FU (furin-like) repeats.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Atrioventricular septal defect 2 antibody
    • AVSD2 antibody
    • CIRRIN antibody
    • CREL1_HUMAN antibody
    • CRELD1 antibody
    • Cysteine rich with EGF like domains 1 antibody
    • Cysteine-rich with EGF-like domain protein 1 antibody
    • DKFZP566D213 antibody
    see all

Images

  • Anti-CRELD1 antibody (ab140346) at 1 µg/ml + Mouse lung lysate at 10 µg

    Predicted band size: 46 kDa

References

This product has been referenced in:

  • D'Alessandro M  et al. CRELD1 is an evolutionarily-conserved maturational enhancer of ionotropic acetylcholine receptors. Elife 7:N/A (2018). Read more (PubMed: 30407909) »
See 1 Publication for this product

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