Overview

  • Product name

    Anti-CRF1/CRHR1 antibody - N-terminal
    See all CRF1/CRHR1 primary antibodies
  • Description

    Rabbit polyclonal to CRF1/CRHR1 - N-terminal
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other human proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Hamster, Cow, Monkey
  • Immunogen

    Synthetic peptide corresponding to Human CRF1/CRHR1 (N terminal). (Extracellular domain).
    Database link: P34998

  • Positive control

    • IHC-P: Human brain amygdala, pituitary, brain glioblastoma, skin melanoma, lung non-small cell carcinoma, brain cerebellum (glia), testis and brain cortex tissues.
  • General notes

     This product was previously labelled as CRF1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab230803 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 - 10 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
  • Tissue specificity

    Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 2 family.
  • Post-translational
    modifications

    C-terminal Ser or Thr residues may be phosphorylated.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Corticotropin releasing factor type 1 receptor antibody
    • corticotropin releasing hormone receptor 1 antibody
    • Corticotropin-releasing factor receptor 1 antibody
    • Corticotropin-releasing hormone receptor 1 antibody
    • CRF R antibody
    • crf receptor 1 antibody
    • crf receptor type 1 antibody
    • crf type 1 antibody
    • CRF-R antibody
    • CRF-R-1 antibody
    • CRF-R1 antibody
    • CRF1 antibody
    • CRFR antibody
    • CRFR-1 antibody
    • CRFR1 antibody
    • CRFR1_HUMAN antibody
    • CRH-R-1 antibody
    • CRH-R1 antibody
    • CRH-R1h antibody
    • CRHR antibody
    • Crhr1 antibody
    • CRHR1f antibody
    • CRHR1L antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human brain amygdala tissue stained for CRF1/CRHR1 with ab230803 at 10 μg/ml in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human pituitary tissue stained for CRF1/CRHR1 with ab230803 at 10 μg/ml in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human brain glioblastoma tissue stained for CRF1/CRHR1 with ab230803 at 10 μg/ml in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human skin melanoma tissue stained for CRF1/CRHR1 with ab230803 at 10 μg/ml in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human lung non-small cell carcinoma tissue stained for CRF1/CRHR1 with ab230803 at 10 μg/ml in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human brain cerebellum (glia) tissue stained for CRF1/CRHR1 with ab230803 at 10 μg/ml in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human testis tissue stained for CRF1/CRHR1 with ab230803 at 10 μg/ml in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded human brain cortex tissue stained for CRF1/CRHR1 with ab230803 at 10 μg/ml in immunohistochemical analysis.

References

ab230803 has not yet been referenced specifically in any publications.

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