Product nameCrizotinib, c-MET and ALK receptor tyrosine kinase inhibitor
DescriptionPotent, selective c-MET and ALK receptor tyrosine kinase inhibitor
- PF 02341066
- PF 2341066
Potent, ATP-competitive inhibitor of c-MET and anaplastic lymphoma kinase (ALK) receptor tyrosine kinases (cell IC50 values are 8.0 and 20 nM respectively). Selective for c-MET and ALK against >120 different kinases. Displays antitumor efficacy in multiple tumor models; inhibits c-MET-dependent proliferation, migration and invasion of human tumor cells in vitro. Orally bioavailable.
Storage instructionsShipped at 4°C. Store at -20°C. Store under desiccating conditions.
Solubility overviewSoluble in DMSO to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Tanizaki J et al. MET tyrosine kinase inhibitor crizotinib (PF-02341066) shows differential antitumor effects in non-small cell lung cancer according to MET alterations. J Thorac Oncol 6:1624-31 (2011). Read more (PubMed: 21716144) »
- Cui JJ et al. Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). J Med Chem 54:6342-63 (2011). Read more (PubMed: 21812414) »
- Zou HY et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res 67:4408-17 (2007). Read more (PubMed: 17483355) »
- Christensen JG et al. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma. Mol Cancer Ther 6:3314-22 (2007). Read more (PubMed: 18089725) »