Cromolyn sodium, macrophage blocker and mast cell stabilizer (ab142857)

Overview

  • Product name

    Cromolyn sodium, macrophage blocker and mast cell stabilizer
  • Description

    Reversible alveolar macrophage blocker and mast cell stabilizer
  • Biological description

    Reversible alveolar macrophage blocker and mast cell stabilizer. Anti-asthmatic and anti-inflammatory agent. Orally active. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    15826-37-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Disodium 5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate
  • Molecular weight

    512.30
  • Molecular formula

    C23H14Na2O11
  • PubChem identifier

    27503
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC2=C(C(=C1)OCC(COC3=CC=CC4=C3C(=O)C=C(O4)C(=O)[O-])O)C(=O)C=C(O2)C(=O)[O-].[Na+].[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Huang P  et al. Mast cells activation contribute to small intestinal ischemia reperfusion induced acute lung injury in rats. Injury 43:1250-6 (2012). Read more (PubMed: 22277108) »
  • Oka T  et al. Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice. Lab Invest 92:1472-82 (2012). Read more (PubMed: 22906983) »
  • Holian A  et al. Mechanistic aspects of cromolyn sodium action on the alveolar macrophage: inhibition of stimulation by soluble agonists. Agents Actions 33:318-25 (1991). Read more (PubMed: 1659157) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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