Overview

  • Product name
    Anti-CROP antibody - C-terminal
    See all CROP primary antibodies
  • Description
    Rabbit polyclonal to CROP - C-terminal
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Cow, Orangutan
  • Immunogen

    Recombinant fragment corresponding to Human CROP aa 356-432 (C terminal).
    Sequence:

    RDRKSYKHRSKSRDREQDRKSKEKEKRGSDDKKSSVKSGSREKQSEDTNT ESKESDTKNEVNGTSEDIKSEGDTQSN


    Database link: O95232

  • Positive control
    • IHC-P: Human lymph node tissue. ICC/IF: A431 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab224409 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml.

Fixation/Permeabilization: PFA/Triton X-100.

Target

  • Function
    Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing.
  • Tissue specificity
    Widely expressed. Highest levels in heart, brain, pancreas, thymus, ovary, small intestine and peripheral blood leukocytes, as well as cerebellum, putamen and pituitary gland. Lowest levels in lung, liver and kidney. Also expressed in fetal tissues, including brain, heart, kidney, thymus and lung.
  • Sequence similarities
    Belongs to the Luc7 family.
  • Post-translational
    modifications
    Phosphorylated in vitro by SRPK1, SRPK2 and CLK1.
  • Cellular localization
    Nucleus speckle. The subnuclear localization is affected by cisplatin.
  • Information by UniProt
  • Database links
  • Alternative names
    • cAMP regulatory element-associated protein 1 antibody
    • Cisplatin resistance-associated overexpressed protein antibody
    • Cisplatin resistance-associated-overexpressed protein antibody
    • CRA antibody
    • CRE-associated protein 1 antibody
    • CREAP-1 antibody
    • CREAP1 antibody
    • CROP antibody
    • hLuc7A antibody
    • LC7L3_HUMAN antibody
    • LUC7 like 3 pre mRNA splicing factor antibody
    • Luc7-like protein 3 antibody
    • Luc7A antibody
    • LUC7L3 antibody
    • O48 antibody
    • OA48 18 antibody
    • Okadaic acid-inducible phosphoprotein OA48-18 antibody
    see all

Images

  • Paraffin-embedded human lymph node tissue stained for CROP using ab224409 at 1/50 dilution in immunohistochemical analysis.

  • PFA-fixed, Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells stained for CROP (green) using ab224409 at 4 µg/ml in ICC/IF.

References

ab224409 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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