Overview

  • Product name
    Anti-Crry antibody [TLD-1C11] (FITC)
    See all Crry primary antibodies
  • Description
    Mouse monoclonal [TLD-1C11] to Crry (FITC)
  • Host species
    Mouse
  • Conjugation
    FITC. Ex: 493nm, Em: 528nm
  • Specificity
    ab106109 can be used to block autoimmune phenomena in rats.
  • Tested applications
    Suitable for: WB, IHC-Fr, Functional Studies, Flow Cyt, ICC/IF, ELISAmore details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    Rat microglial cells

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C.
  • Storage buffer
    Preservative: None
    Constituents: 0.1% BSA, PBS
  • Concentration information loading...
  • Purity
    Protein G purified
  • Purification notes
    0.2 µm filtered antibody solution
  • Clonality
    Monoclonal
  • Clone number
    TLD-1C11
  • Isotype
    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab106109 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 62 kDa.
IHC-Fr Use at an assay dependent concentration.
Functional Studies Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration.

ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

 

ICC/IF Use at an assay dependent concentration.
ELISA Use at an assay dependent concentration.

Target

  • Function
    Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Seems to act as a costimulatory factor for T-cells. May play a crucial role in early embryonic development by maintaining fetomaternal tolerance.
  • Sequence similarities
    Contains 7 Sushi (CCP/SCR) domains.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Antigen 5I2 antibody
    • Complement C4b binding protein CR 1 like protein antibody
    • Complement component (3b/4b) receptor 1 like antibody
    • Complement component receptor 1 like protein antibody
    • Complement regulatory protein Crry antibody
    • CR1L antibody
    • Crry antibody
    • CRRY_RAT antibody
    • MGC129536 antibody
    see all

References

This product has been referenced in:
  • Huang G  et al. Characterization of transfusion-elicited acute antibody-mediated rejection in a rat model of kidney transplantation. Am J Transplant 14:1061-72 (2014). Read more (PubMed: 24708533) »
  • Fraser DA  et al. Bacterial expression and membrane targeting of the rat complement regulator Crry: a new model anticomplement therapeutic. Protein Sci 11:2512-21 (2002). Read more (PubMed: 12237472) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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