CRT0044876 (7-Nitroindole-2-carboxylic acid), APE1 inhibitor (ab145856)

Overview

  • Product name

    CRT0044876 (7-Nitroindole-2-carboxylic acid), APE1 inhibitor
  • Description

    Selective APE1 inhibitor
  • Biological description

    Selective APE1 inhibitor (IC50 = 3 μM). Binds to the active site of APE1 and inhibits the AP endonuclease, 3'-phosphodiesterase and 3'-phosphatase. Potentiates the cytotoxicity of several DNA base-targeting compounds.
  • Purity

    > 97%
  • CAS Number

    6960-45-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    7-Nitro-1H-indole-2-carboxylic acid
  • Molecular weight

    206.15
  • Molecular formula

    C9H6N2O4
  • PubChem identifier

    81409
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 4 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC2=C(C(=C1)[N+](=O)[O-])NC(=C2)C(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Bie J  et al. Design, synthesis and biological evaluation of 7-nitro-1H-indole-2-carboxylic acid derivatives as allosteric inhibitors of fructose-1,6-bisphosphatase. Bioorg Med Chem 22:1850-62 (2014). Read more (PubMed: 24530031) »
  • Naidu MD  et al. Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein binding. PLoS One 6:e23679 (2011). Read more (PubMed: 21935361) »
  • Madhusudan S  et al. Isolation of a small molecule inhibitor of DNA base excision repair. Nucleic Acids Res 33:4711-24 (2005). Read more (PubMed: 16113242) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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