Overview

  • Product name

    CRT0066101, protein kinase D inhibitor
  • Description

    Potent and selective protein kinase D inhibitor
  • Biological description

    Potent and selective protein kinase D inhibitor (IC50 values are 1, 2 and 2.5 nM at PKD1, PKD3 and PKD2, respectively). Reduces proliferation of pancreatic cancer cells. Orally active. Antitumor agent. Active in vivo and in vitro.

    Also available in simple stock solutions (ab146740) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity

    > 99%
  • General notes

    Sold under license from CRT
  • CAS Number

    1883545-60-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[4-[[(2R)-2-Aminobutyl]amino]pyrimidin-2-yl]-4-(1-methyl-1H-pyrazol-4-yl)phenol dihydrochloride
  • Molecular weight

    411.33
  • Molecular formula

    C18H22N6O.2HCl
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.Cl.Cn1cc(cn1)c3cc(c2nc(NC[C@H](N)CC)ccn2)c(O)cc3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Wei N  et al. Protein kinase d as a potential chemotherapeutic target for colorectal cancer. Mol Cancer Ther 13:1130-41 (2014). Read more (PubMed: 24634417) »
  • Bernhart E  et al. Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro. Exp Cell Res 319:2037-48 (2013). Read more (PubMed: 23562655) »
  • Yang ZF  et al. GABP transcription factor is required for development of chronic myelogenous leukemia via its control of PRKD2. Proc Natl Acad Sci U S A 110:2312-7 (2013). Read more (PubMed: 23345428) »
  • Yuan J  et al. Protein kinase d regulates cell death pathways in experimental pancreatitis. Front Physiol 3:60 (2012). Read more (PubMed: 22470346) »
  • Young SH  et al. Rapid protein kinase D1 signaling promotes migration of intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 303:G356-66 (2012). Read more (PubMed: 22595992) »
  • Ochi N  et al. Protein kinase D1 promotes anchorage-independent growth, invasion, and angiogenesis by human pancreatic cancer cells. J Cell Physiol 226:1074-81 (2011). Read more (PubMed: 20857418) »
  • Harikumar KB  et al. A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo. Mol Cancer Ther 9:1136-46 (2010). Read more (PubMed: 20442301) »
See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

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