CRT5, protein kinase D inhibitor (ab146825)

Overview

  • Product name

    CRT5, protein kinase D inhibitor
  • Description

    Potent, selective protein kinase D inhibitor
  • Alternative names

    • CRT0066051
    • PKD inhibitor
  • Biological description

    Potent, selective, pyrazine benzamide protein kinase D inhibitor (IC50 values are 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3 respectively). Blocks phosphorylation of PKD1 on Ser916 and PKD2 on Ser876, but does not affect PKC-dependent PKD phosphorylation. Decreases VEGF-induced endothelial migration, proliferation and tubulogenesis.

  • Purity

    > 97%
  • CAS Number

    1034297-58-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[6-Amino-5-(6-ethoxy-2-naphthalenyl)-3-pyridinyl]-N-[2-(dimethylamino)ethyl]benzamide dihydrochloride

  • Molecular weight

    527.49
  • Molecular formula

    C28H30N4O2.2HCl
  • PubChem identifier

    58238286
  • Storage instructions

    Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Cl.Cl.Nc3ncc(cc3c1ccc2cc(OCC)ccc2c1)c4cccc(c4)C(=O)NCCN(C)C
  • Source

    Synthetic

References

ab146825 has not yet been referenced specifically in any publications.

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