Anti-CSF-1-R antibody [MM0467-5V36] (ab89907)

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Overview

  • Product name

    Anti-CSF-1-R antibody [MM0467-5V36]
    See all CSF-1-R primary antibodies

  • Description

    Mouse monoclonal [MM0467-5V36] to CSF-1-R

  • Host species

    Mouse

  • Tested applications

    Suitable for: WB, Neutralisingmore details

  • Species reactivity

    Reacts with: Human

  • Immunogen

    Recombinant fragment corresponding to Human CSF-1-R (extracellular).

Properties

Applications

Our Abpromise guarantee covers the use of ab89907 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 108 kDa.
Neutralising Use at an assay dependent dilution.

Target

  • Function

    Protein tyrosine-kinase transmembrane receptor for CSF1 and IL34.

  • Tissue specificity

    Expressed in bone marrow and in differentiated blood mononuclear cells.

  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.

  • Cellular localization

    Membrane.
  • Information by UniProt

  • Database links

    • Alternative names

      • C FMS antibody
      • CD 115 antibody
      • CD115 antibody
      • CD115 antigen antibody
      • CFMS antibody
      • Colony stimulating factor 1 receptor antibody
      • Colony stimulating factor I receptor antibody
      • CSF 1 R antibody
      • CSF 1R antibody
      • CSF-1 receptor antibody
      • CSF-1-R antibody
      • CSF1 R antibody
      • CSF1R antibody
      • CSF1R_HUMAN antibody
      • CSFR antibody
      • EC 2.7.10.1 antibody
      • FIM 2 antibody
      • FIM2 antibody
      • FMS antibody
      • FMS proto oncogene antibody
      • FMS protooncogene antibody
      • HDLS antibody
      • M-CSF Receptor antibody
      • M-CSF-R antibody
      • Macrophage colony stimulating factor 1 receptor antibody
      • Macrophage colony stimulating factor I receptor antibody
      • Macrophage colony-stimulating factor 1 receptor antibody
      • McDonough feline sarcoma viral (v fms) oncogene homolog antibody
      • MCSFR antibody
      • Oncogen FMS antibody
      • Proto-oncogene c-Fms antibody
      • V-FMS McDonough feline sarcoma viral oncogen homolog, formerly antibody
      see all

    References

    This product has been referenced in:

    • Nijaguna MB  et al. Glioblastoma-derived Macrophage Colony-stimulating Factor (MCSF) Induces Microglial Release of Insulin-like Growth Factor-binding Protein 1 (IGFBP1) to Promote Angiogenesis. J Biol Chem 290:23401-15 (2015). Read more (PubMed: 26245897) »
    See 1 Publication for this product

    Publishing research using ab89907? Please let us know so that we can cite the reference in this datasheet.

    Customer reviews and Q&As

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    Question

    Please could you let me know when the following antibody was first available to buy?

    Please also let me know if you have any information regarding where this antibody binds to the receptor.

    Many thanks in advance,

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    Answer

    Thank you for contacting us and your interest in our products.

    The anti-MCSF Receptor antibody [MM0467-5V36] (ab89907) was first added to our catalogue in February 2010.

    The antibody is raised against the extracellular domain of the MCSF receptor (recombinantly expressed human protein of residues 20-510, SwissProt reference P07333). We have not performed any further epitope mapping and I am therefore unable to tell you exactly where within this region the antibody binds.

    I hope this information has been of help. If you have any further questions please do not hesitate to ask.

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