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    csf-1-r-antibody-mm0467-5v36-ab89907.pdf

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Cardiovascular Angiogenesis Cytokines Other
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Anti-CSF-1-R antibody [MM0467-5V36] (ab89907)

  • Datasheet
Submit a review Q&A (1)References (1)

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Key features and details

  • Mouse monoclonal [MM0467-5V36] to CSF-1-R
  • Reacts with: Human
  • Isotype: IgG1

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Secondary
Product image
Goat Anti-Mouse IgG H&L (HRP) (ab205719)

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Overview

  • Product name

    Anti-CSF-1-R antibody [MM0467-5V36]
    See all CSF-1-R primary antibodies
  • Description

    Mouse monoclonal [MM0467-5V36] to CSF-1-R
  • Host species

    Mouse
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human CSF-1-R (extracellular).

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    Constituent: PBS
  • Concentration information loading...
  • Purity

    Protein G purified
  • Purification notes

    The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and 0.2 µm filtered.
  • Clonality

    Monoclonal
  • Clone number

    MM0467-5V36
  • Isotype

    IgG1
  • Research areas

    • Cardiovascular
    • Angiogenesis
    • Cytokines
    • Other
    • Immunology
    • Innate Immunity
    • Macrophage / Inflamm.
    • Immunology
    • Innate Immunity
    • Cytokines
    • CSFs
    • Signal Transduction
    • Protein Phosphorylation
    • Ser / Thr Kinases
    • Other Kinases

Associated products

  • Compatible Secondaries

    • Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113)
    • Goat Anti-Mouse IgG H&L (HRP) (ab205719)
  • Isotype control

    • Mouse IgG1, kappa monoclonal [15-6E10A7] - Isotype Control (ab170190)

Target

  • Function

    Protein tyrosine-kinase transmembrane receptor for CSF1 and IL34.
  • Tissue specificity

    Expressed in bone marrow and in differentiated blood mononuclear cells.
  • Sequence similarities

    Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.
    Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • Cellular localization

    Membrane.
  • Target information above from: UniProt accession P07333 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 1436 Human
    • Omim: 164770 Human
    • SwissProt: P07333 Human
    • Unigene: 586219 Human
    • Alternative names

      • C FMS antibody
      • CD 115 antibody
      • CD115 antibody
      • CD115 antigen antibody
      • CFMS antibody
      • Colony stimulating factor 1 receptor antibody
      • Colony stimulating factor I receptor antibody
      • CSF 1 R antibody
      • CSF 1R antibody
      • CSF-1 receptor antibody
      • CSF-1-R antibody
      • CSF1 R antibody
      • CSF1R antibody
      • CSF1R_HUMAN antibody
      • CSFR antibody
      • EC 2.7.10.1 antibody
      • FIM 2 antibody
      • FIM2 antibody
      • FMS antibody
      • FMS proto oncogene antibody
      • FMS protooncogene antibody
      • HDLS antibody
      • M-CSF Receptor antibody
      • M-CSF-R antibody
      • Macrophage colony stimulating factor 1 receptor antibody
      • Macrophage colony stimulating factor I receptor antibody
      • Macrophage colony-stimulating factor 1 receptor antibody
      • McDonough feline sarcoma viral (v fms) oncogene homolog antibody
      • MCSFR antibody
      • Oncogen FMS antibody
      • Proto-oncogene c-Fms antibody
      • V-FMS McDonough feline sarcoma viral oncogen homolog, formerly antibody
      see all

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (1)

    Publishing research using ab89907? Please let us know so that we can cite the reference in this datasheet.

    ab89907 has been referenced in 1 publication.

    • Nijaguna MB  et al. Glioblastoma-derived Macrophage Colony-stimulating Factor (MCSF) Induces Microglial Release of Insulin-like Growth Factor-binding Protein 1 (IGFBP1) to Promote Angiogenesis. J Biol Chem 290:23401-15 (2015). PubMed: 26245897

    Customer reviews and Q&As

    Show All Reviews Q&A
    Submit a review Submit a question

    Question

    Please could you let me know when the following antibody was first available to buy?

    Please also let me know if you have any information regarding where this antibody binds to the receptor.

    Many thanks in advance,

    Read More

    Abcam community

    Verified customer

    Asked on Jul 16 2012

    Answer

    Thank you for contacting us and your interest in our products.

    The anti-MCSF Receptor antibody [MM0467-5V36] (ab89907) was first added to our catalogue in February 2010.

    The antibody is raised against the extracellular domain of the MCSF receptor (recombinantly expressed human protein of residues 20-510, SwissProt reference P07333). We have not performed any further epitope mapping and I am therefore unable to tell you exactly where within this region the antibody binds.

    I hope this information has been of help. If you have any further questions please do not hesitate to ask.

    Read More

    Abcam Scientific Support

    Answered on Jul 16 2012

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

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