Overview

  • Product name

    Anti-CSN4 antibody [EPR7453]
    See all CSN4 primary antibodies
  • Description

    Rabbit monoclonal [EPR7453] to CSN4
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
    Unsuitable for: Flow Cyt,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human CSN4 aa 1-100 (N terminal). The exact sequence is proprietary.

  • Positive control

    • SH-SY5Y, HepG2, HeLa and PC3 cell lysates.
  • General notes

     

     

     This product was previously labelled as COPS4

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab139688 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 46 kDa.
ICC/IF 1/50 - 1/100.
  • Application notes
    Is unsuitable for Flow Cyt,IHC-P or IP.
  • Target

    • Function

      Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
    • Sequence similarities

      Belongs to the CSN4 family.
      Contains 1 PCI domain.
    • Cellular localization

      Cytoplasm. Nucleus.
    • Information by UniProt
    • Database links

    • Alternative names

      • CH4 antibody
      • COP9 (constitutive photomorphogenic) homolog subunit 4 antibody
      • COP9 complex homolog subunit 4 antibody
      • COP9 complex S4 antibody
      • COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) antibody
      • COP9 constitutive photomorphogenic homolog subunit 4 antibody
      • COP9 signalosome complex subunit 4 antibody
      • COP9 signalosome subunit 4 antibody
      • COPS4 antibody
      • CSN complex subunit 4 antibody
      • CSN4 antibody
      • CSN4 SCHPO antibody
      • CSN4_HUMAN antibody
      • DCH4 antibody
      • JAB1 containing signalosome subunit 4 antibody
      • JAB1-containing signalosome subunit 4 antibody
      • MGC94896 antibody
      • SGN4 antibody
      • Signalosome subunit 4 antibody
      see all

    Images

    • All lanes : Anti-CSN4 antibody [EPR7453] (ab139688) at 1/1000 dilution

      Lane 1 : SH-SY5Y cell lysate
      Lane 2 : HepG2 cell lysate
      Lane 3 : HeLa cell lysate
      Lane 4 : PC3 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution

      Predicted band size: 46 kDa

    References

    This product has been referenced in:

    • Manjarrez JR  et al. Hsp90-dependent assembly of the DBC2/RhoBTB2-Cullin3 E3-ligase complex. PLoS One 9:e90054 (2014). WB ; Human . Read more (PubMed: 24608665) »
    See 1 Publication for this product

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab139688.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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