Overview

  • Product name

    Anti-CSN7A antibody [EPR6463]
    See all CSN7A primary antibodies
  • Description

    Rabbit monoclonal [EPR6463] to CSN7A
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP
  • Species reactivity

    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human CSN7A aa 200-300.
    Database link: Q9UBW8

  • Positive control

    • HeLa, JAR, human fetal muscle, brain, heart, and kidney lysates.
  • General notes

    Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.

     

     This product was previously labelled as COPS7A

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab124705 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 30 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
  • Target

    • Function

      Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
    • Tissue specificity

      Widely expressed. Expressed at high level in brain, heart and skeletal muscle.
    • Sequence similarities

      Belongs to the CSN7/EIF3M family. CSN7 subfamily.
      Contains 1 PCI domain.
    • Post-translational
      modifications

      Phosphorylated by CK2 and PKD kinases.
    • Cellular localization

      Cytoplasm. Nucleus.
    • Information by UniProt
    • Database links

    • Alternative names

      • COP9 complex subunit 7a antibody
      • COP9 constitutive photomorphogenic homolog subunit 7A antibody
      • COP9 signalosome complex subunit 7a antibody
      • COP9 signalosome subunit 7A antibody
      • COPS7A antibody
      • CSN7A antibody
      • CSN7A_HUMAN antibody
      • Dermal papilla derived protein 10 antibody
      • Dermal papilla-derived protein 10 antibody
      • DERP10 antibody
      • JAB1 containing signalosome subunit 7a antibody
      • JAB1-containing signalosome subunit 7a antibody
      • SGN7a antibody
      • Signalosome subunit 7a antibody
      see all

    Images

    • All lanes : Anti-CSN7A antibody [EPR6463] (ab124705) at 1/1000 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : JAR cell lysate
      Lane 3 : Human fetal muscle cell lysate
      Lane 4 : Human brain cell lysate
      Lane 5 : Human heart cell lysate
      Lane 6 : Human kidney cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 30 kDa



      Standard HRP labelled goat anti-rabbit at 1:2000.
    • Equilibrium disassociation constant (KD)
      Learn more about KD

      Click here to learn more about KD

    References

    ab124705 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab124705.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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