Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR6463] to CSN7A
- Suitable for: WB
- Reacts with: Rat, Human
Product nameAnti-CSN7A antibody [EPR6463]
See all CSN7A primary antibodies
DescriptionRabbit monoclonal [EPR6463] to CSN7A
Tested applicationsSuitable for: WBmore details
Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP
Species reactivityReacts with: Rat, Human
Synthetic peptide corresponding to Human CSN7A aa 200-300.
Database link: Q9UBW8
- HeLa, JAR, human fetal muscle, brain, heart, and kidney lysates.
Mouse: We have preliminary internal testing data to indicate this antibody may not react with this species. Please contact us for more information.
This product was previously labelled as COPS7A
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Dissociation constant (KD)KD = 1.35 x 10 -10 M Learn more about KD
Storage bufferpH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant
Concentration information loading...
PurityTissue culture supernatant
Our Abpromise guarantee covers the use of ab124705 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000 - 1/10000. Predicted molecular weight: 30 kDa.|
FunctionComponent of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Tissue specificityWidely expressed. Expressed at high level in brain, heart and skeletal muscle.
Sequence similaritiesBelongs to the CSN7/EIF3M family. CSN7 subfamily.
Contains 1 PCI domain.
modificationsPhosphorylated by CK2 and PKD kinases.
Cellular localizationCytoplasm. Nucleus.
- Information by UniProt
- COP9 complex subunit 7a antibody
- COP9 constitutive photomorphogenic homolog subunit 7A antibody
- COP9 signalosome complex subunit 7a antibody
All lanes : Anti-CSN7A antibody [EPR6463] (ab124705) at 1/1000 dilution
Lane 1 : HeLa cell lysate
Lane 2 : JAR cell lysate
Lane 3 : Human fetal muscle cell lysate
Lane 4 : Human brain cell lysate
Lane 5 : Human heart cell lysate
Lane 6 : Human kidney cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 30 kDa
Standard HRP labelled goat anti-rabbit at 1:2000.
Equilibrium disassociation constant (KD)
Learn more about KD
Click here to learn more about KD
ab124705 has not yet been referenced specifically in any publications.