• Product name

  • Description

    Rabbit polyclonal to CSRP3
  • Host species

  • Tested applications

    Suitable for: IHC-P, IHC-Fr, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from the C-terminal domain of Human CSRP3



Our Abpromise guarantee covers the use of ab73142 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
WB 1/500 - 1/5000. Predicted molecular weight: 21 kDa.


  • Function

    Positive regulator of myogenesis. Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation.
  • Tissue specificity

    Cardiac and slow-twitch skeletal muscles.
  • Involvement in disease

    Defects in CSRP3 are the cause of cardiomyopathy dilated type 1M (CMD1M) [MIM:607482]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
    Defects in CSRP3 are the cause of cardiomyopathy familial hypertrophic type 12 (CMH12) [MIM:612124]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • Sequence similarities

    Contains 2 LIM zinc-binding domains.
  • Cellular localization

    Nucleus. Cytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > myofibril > sarcomere > Z line. Mainly cytoplasmic (By similarity). In the nucleus it associates with the actin cytoskeleton (Potential). In the Z line, found associated with GLRX3.
  • Information by UniProt
  • Database links

  • Alternative names

    • cardiac antibody
    • Cardiac LIM protein antibody
    • CLP antibody
    • CMD1M antibody
    • CMH12 antibody
    • CRP3 antibody
    • Csrp3 antibody
    • CSRP3_HUMAN antibody
    • Cysteine and glycine-rich protein 3 antibody
    • Cysteine rich protein 3 antibody
    • Cysteine-rich protein 3 antibody
    • LIM domain only 4 antibody
    • LIM domain protein antibody
    • LMO4 antibody
    • MLP antibody
    • Muscle LIM protein antibody
    see all


ab73142 has not yet been referenced specifically in any publications.

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