Overview

  • Product name
  • Description
    Rabbit polyclonal to CTC1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: Flow Cyt, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human CTC1 aa 774-803 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q2NKJ3

  • Positive control
    • K562 cell line lysate; K562 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab175074 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/10 - 1/50.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

 

WB 1/100 - 1/500. Predicted molecular weight: 135 kDa.

Target

  • Function
    Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.
  • Involvement in disease
    Cerebroretinal microangiopathy with calcifications and cysts
  • Sequence similarities
    Belongs to the CTC1 family.
  • Cellular localization
    Nucleus. Chromosome > telomere. A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo.
  • Information by UniProt
  • Database links
  • Alternative names
    • CTC1 antibody
    • C17orf68 antibody
    • Conserved telomere maintenance component 1 antibody
    • CST complex subunit CTC1 antibody
    • CTC1 antibody
    • CTC1_HUMAN antibody
    • HBV DNAPTP1-transactivated protein B antibody
    see all

Images

  • Anti-CTC1 antibody (ab175074) at 1/100 dilution + K562 cell line lysate at 35 µg

    Predicted band size: 135 kDa

  • Flow Cytometrical analysis ofK562 cells with ab175074 antibody at a dilution of 1/10 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

References

This product has been referenced in:
  • Wang Y & Chai W Pathogenic CTC1 mutations cause global genome instabilities under replication stress. Nucleic Acids Res 46:3981-3992 (2018). Human . Read more (PubMed: 29481669) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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