Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.
Involvement in disease
Cerebroretinal microangiopathy with calcifications and cysts
Belongs to the CTC1 family.
Nucleus. Chromosome > telomere. A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo.
Anti-CTC1 antibody (ab175074) at 1/100 dilution + K562 cell line lysate at 35 µg
Predicted band size: 135 kDa
Flow Cytometry - Anti-CTC1 antibody (ab175074)
Flow Cytometrical analysis ofK562 cells with ab175074 antibody at a dilution of 1/10 (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.