Overview

  • Product name

    Anti-CTC1 antibody
  • Description

    Rabbit polyclonal to CTC1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: Flow Cyt, IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human CTC1 aa 767-795 (internal sequence) conjugated to keyhole limpet haemocyanin.
    Database link: Q2NKJ3

  • Positive control

    • WB: K562 whole cell lysate. IHC-P: Human kidney tissue. Flow Cytometry: K562 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab230538 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt 1/10 - 1/50.
IHC-P 1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
WB 1/1000. Predicted molecular weight: 135 kDa.

Target

  • Function

    Component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.
  • Involvement in disease

    Cerebroretinal microangiopathy with calcifications and cysts
  • Sequence similarities

    Belongs to the CTC1 family.
  • Cellular localization

    Nucleus. Chromosome > telomere. A transmembrane region is predicted by sequence analysis tools (ESKW, MEMSAT and Phobius); however, given the telomeric localization of the protein, the relevance of the transmembrane region is unsure in vivo.
  • Information by UniProt
  • Database links

  • Alternative names

    • CTC1 antibody
    • C17orf68 antibody
    • Conserved telomere maintenance component 1 antibody
    • CST complex subunit CTC1 antibody
    • CTC1 antibody
    • CTC1_HUMAN antibody
    • HBV DNAPTP1-transactivated protein B antibody
    see all

Images

  • Formalin-fixed, parafin-embedded human kidney tissue stained for CTC1 using ab230538 at 1/50 dilution in immunohistochemical analysis.

  • Anti-CTC1 antibody (ab230538) at 1/1000 dilution + K562 (human chronic myelogenous leukemia cell line from bone marrow ) whole cell lysate at 35 µg

    Developed using the ECL technique.

    Predicted band size: 135 kDa

  • Flow cytometric analysis of K562 (human chronic myelogenous leukemia cell line from bone marrow ) cell line labeling CTC1 with ab230538 at 1/10 dilution (green) compared with a negative control (blue). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

References

ab230538 has not yet been referenced specifically in any publications.

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