Anti-CTGF antibody (ab6992)
Key features and details
- Rabbit polyclonal to CTGF
- Reacts with: Mouse, Rat, Sheep, Human
- Isotype: IgG
Overview
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Product name
Anti-CTGF antibody
See all CTGF primary antibodies -
Description
Rabbit polyclonal to CTGF -
Host species
Rabbit -
Species reactivity
Reacts with: Mouse, Rat, Sheep, Human
Predicted to work with: Cow
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Immunogen
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Positive control
- human hippocampal protein extracts (see Ueberham et al paper).
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General notes
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
Target
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Function
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. -
Tissue specificity
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. -
Sequence similarities
Belongs to the CCN family.
Contains 1 CTCK (C-terminal cystine knot-like) domain.
Contains 1 IGFBP N-terminal domain.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain. -
Cellular localization
Secreted > extracellular space > extracellular matrix. Secreted. - Information by UniProt
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Database links
- Entrez Gene: 281103 Cow
- Entrez Gene: 1490 Human
- Entrez Gene: 14219 Mouse
- Entrez Gene: 64032 Rat
- Omim: 121009 Human
- SwissProt: O18739 Cow
- SwissProt: P29279 Human
- SwissProt: P29268 Mouse
see all -
Alternative names
- CCN 2 antibody
- CCN family member 2 antibody
- CCN2 antibody
see all
Protocols
References (214)
ab6992 has been referenced in 214 publications.
- Wilson DH et al. Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors. Nat Commun 11:445 (2020). PubMed: 31974352
- Cao Y et al. BAFF is involved in the pathogenesis of IgA nephropathy by activating the TRAF6/NF-?B signaling pathway in glomerular mesangial cells. Mol Med Rep 21:795-805 (2020). PubMed: 31974601
- Yu Q et al. Antifibrotic effects of specific siRNA targeting connective tissue growth factor delivered by polyethyleneimine-functionalized magnetic iron oxide nanoparticles on LX-2 cells. Mol Med Rep 21:181-190 (2020). PubMed: 31746398
- Fallah M et al. Plasminogen is a master regulator and a potential drug candidate for the healing of radiation wounds. Cell Death Dis 11:201 (2020). PubMed: 32205839
- Omori H et al. YAP1 is a potent driver of the onset and progression of oral squamous cell carcinoma. Sci Adv 6:eaay3324 (2020). PubMed: 32206709
