Anti-CTGF antibody (ab6992)
Key features and details
- Rabbit polyclonal to CTGF
- Suitable for: IHC-P, ICC/IF, IHC-FoFr, WB, IHC-Fr, IP
- Reacts with: Mouse, Rat, Sheep, Human
- Isotype: IgG
Get better batch-to-batch reproducibility with a recombinant antibody
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Overview
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Product name
Anti-CTGF antibody
See all CTGF primary antibodies -
Description
Rabbit polyclonal to CTGF -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, ICC/IF, IHC-FoFr, WB, IHC-Fr, IPmore details -
Species reactivity
Reacts with: Mouse, Rat, Sheep, Human
Predicted to work with: Cow
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Immunogen
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Positive control
- human hippocampal protein extracts (see Ueberham et al paper).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab6992 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | (10) |
Use at an assay dependent concentration.
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| ICC/IF | (4) |
Use at an assay dependent concentration.
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| IHC-FoFr | (1) |
Use at an assay dependent concentration.
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| WB | (10) |
Use at an assay dependent concentration. Predicted molecular weight: 38 kDa.
Block membrane in 4% BSA in Tris-buffered saline containing 0.05% Tween 20 (TBST). See Fu M et al. |
| IHC-Fr | (2) |
Use at an assay dependent concentration.
See Ueberham et al. |
| IP |
Use at an assay dependent concentration. PubMed: 16100286
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| Notes |
|---|
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IHC-P
Use at an assay dependent concentration. |
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ICC/IF
Use at an assay dependent concentration. |
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IHC-FoFr
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. Predicted molecular weight: 38 kDa. Block membrane in 4% BSA in Tris-buffered saline containing 0.05% Tween 20 (TBST). See Fu M et al. |
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IHC-Fr
Use at an assay dependent concentration. See Ueberham et al. |
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IP
Use at an assay dependent concentration. PubMed: 16100286 |
Target
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Function
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. -
Tissue specificity
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. -
Sequence similarities
Belongs to the CCN family.
Contains 1 CTCK (C-terminal cystine knot-like) domain.
Contains 1 IGFBP N-terminal domain.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain. -
Cellular localization
Secreted > extracellular space > extracellular matrix. Secreted. - Information by UniProt
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Database links
- Entrez Gene: 281103 Cow
- Entrez Gene: 1490 Human
- Entrez Gene: 14219 Mouse
- Entrez Gene: 64032 Rat
- Omim: 121009 Human
- SwissProt: O18739 Cow
- SwissProt: P29279 Human
- SwissProt: P29268 Mouse
see all -
Alternative names
- CCN 2 antibody
- CCN family member 2 antibody
- CCN2 antibody
see all
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (261)
ab6992 has been referenced in 261 publications.
- Zhang Y et al. miR-212 promotes renal interstitial fibrosis by inhibiting hypoxia-inducible factor 1-a inhibitor. Mol Med Rep 23:N/A (2021). PubMed: 33495813
- Lyu L et al. Scoparone alleviates Ang II-induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress. J Cell Mol Med 25:3136-3148 (2021). PubMed: 33560596
- Zhu F et al. Tubular Numb promotes renal interstitial fibrosis via modulating HIF-1a protein stability. Biochim Biophys Acta Mol Basis Dis 1867:166081 (2021). PubMed: 33486098
- Tokuda K et al. Development of a novel knee contracture mouse model by immobilization using external fixation. Connect Tissue Res N/A:1-14 (2021). PubMed: 33602048
- Liu Y et al. Inhibiting miR-1 attenuates pulmonary arterial hypertension in rats. Mol Med Rep 23:N/A (2021). PubMed: 33604679