Overview

  • Product name

  • Description

    Rabbit polyclonal to CUG-BP1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Zebrafish
  • Immunogen

    Recombinant fragment within Zebrafish CUG-BP1 aa 2-239. The exact sequence is proprietary.
    Database link: Q9IBD0

  • Positive control

    • Zebrafish eye whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab209712 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 54 kDa.

Target

  • Function

    RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver.
  • Tissue specificity

    Ubiquitous.
  • Sequence similarities

    Belongs to the CELF/BRUNOL family.
    Contains 3 RRM (RNA recognition motif) domains.
  • Post-translational
    modifications

    Phosphorylated. Its phosphorylation status increases in senescent cells.
  • Cellular localization

    Nucleus. Cytoplasm. RNA-binding activity is detected in both nuclear and cytoplasmic compartments.
  • Information by UniProt
  • Database links

    • Alternative names

      • 50 kDa Nuclear polyadenylated RNA binding protein antibody
      • 50 kDa nuclear polyadenylated RNA-binding protein antibody
      • Bruno like 2 antibody
      • bruno like protein 2 antibody
      • Bruno-like protein 2 antibody
      • BRUNOL 2 antibody
      • BRUNOL2 antibody
      • CELF 1 antibody
      • CELF-1 antibody
      • celf1 antibody
      • CELF1 CUGBP, Elav like family member 1 antibody
      • CELF1_HUMAN antibody
      • CUG BP and ETR 3 like factor 1 antibody
      • CUG BP antibody
      • CUG BP1 antibody
      • CUG RNA binding protein antibody
      • CUG triplet repeat RNA binding protein 1 antibody
      • CUG triplet repeat RNA-binding protein 1 antibody
      • CUG-BP antibody
      • CUG-BP- and ETR-3-like factor 1 antibody
      • CUG-BP1 antibody
      • CUGBP 1 antibody
      • CUGBP and ETR3 like factor 1 antibody
      • CUGBP antibody
      • CUGBP Elav like family member 1 antibody
      • CUGBP Elav-like family member 1 antibody
      • CUGBP1 antibody
      • Cytidine uridine guanosine binding protein 1 antibody
      • Deadenylation factor CUG BP antibody
      • Deadenylation factor CUG-BP antibody
      • Deadenylation factor CUGBP antibody
      • EDEN BP antibody
      • EDEN BP homolog antibody
      • EDEN-BP antibody
      • EDEN-BP homolog antibody
      • embryo deadenylation element binding protein antibody
      • embryo deadenylation element binding protein homolog antibody
      • Embryo deadenylation element-binding protein homolog antibody
      • hNab 50 antibody
      • hNab50 antibody
      • NAB 50 antibody
      • NAB50 antibody
      • NAPOR antibody
      • Nuclear polyadenylated RNA binding protein 50 kD antibody
      • Nuclear polyadenylated RNA binding protein antibody
      • RNA binding protein BRUNOL 2 antibody
      • RNA binding protein BRUNOL2 antibody
      • RNA-binding protein BRUNOL-2 antibody
      see all

    Images

    • Anti-CUG-BP1 antibody (ab209712) at 1/1000 dilution + Zebrafish eye whole cell lysate at 30 µg

      Predicted band size: 54 kDa



      10% SDS PAGE

    References

    ab209712 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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