Product nameCurvularin, Antibiotic agent
DescriptionAntibiotic agent. JAK signal inhibitor.
Biological descriptionAntibiotic agent. Janus tyrosine kinase (JAK) signal inhibitor. Cell division inhibitor. AChE inhibitor. Inhibits iNOS and NOSII expression. Shows antibacterial, antifungal and antiprotozoal effects. Shows anti-inflammatory effects in vivo.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol and in DMSO
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Signal transduction
- Nitric oxide & oxidative stress
This product has been referenced in:
- Schmidt N et al. The anti-inflammatory fungal compound (S)-curvularin reduces proinflammatory gene expression in an in vivo model of rheumatoid arthritis. J Pharmacol Exp Ther 343:106-14 (2012). Read more (PubMed: 22767531) »
- Elzner S et al. Inhibitors of inducible NO synthase expression: total synthesis of (S)-curvularin and its ring homologues. ChemMedChem 3:924-39 (2008). Read more (PubMed: 18366037) »
- Vesonder RF et al. Curvularin from penicillium baradicum Baghdadi NRRL 3754, and biological effects. J Environ Sci Health B 11:289-71 (1976). Read more (PubMed: 1002951) »