CX 546, AMPA receptor potentiator (ab146123)

Overview

  • Product name

    CX 546, AMPA receptor potentiator
  • Description

    AMPA receptor potentiator
  • Biological description

    AMPA receptor potentiator. Selectively binds to the agonist bound non-desensitized receptor. Destabilizes desensitized receptor conformation with greater potency than CX516. Enhances cognitive function in vivo.
  • Purity

    > 99%
  • CAS Number

    215923-54-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone
  • Molecular weight

    247.29
  • Molecular formula

    C14H17NO3
  • PubChem identifier

    2890
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CCN(CC1)C(=O)C2=CC3=C(C=C2)OCCO3
  • Source

    Synthetic

References

This product has been referenced in:

  • O'Neill MJ & Witkin JM AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets 8:603-20 (2007). Read more (PubMed: 17504104) »
  • O'Neill MJ  et al. AMPA receptor potentiators for the treatment of CNS disorders. Curr Drug Targets CNS Neurol Disord 3:181-94 (2004). Read more (PubMed: 15180479) »
  • Nagarajan N  et al. Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546. Neuropharmacology 41:650-63 (2001). Read more (PubMed: 11640919) »

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