CX3CR1 peptide (ab8124)

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Overview

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab8124 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

General Info

  • Alternative names
    • Beta chemokine receptor-like 1
    • C X3 C CKR 1
    • C-X3-C CKR-1
    • CCRL1
    • Chemokine C X3 C motif receptor 1
    • CMK BRL 1
    • CMK-BRL-1
    • CMK-BRL1
    • CMKBLR1
    • CMKDR1
    • CX3C chemokine receptor 1
    • CX3C CKR1
    • CX3C1_HUMAN
    • CX3CR1
    • Fractalkine receptor
    • G-protein coupled receptor 13
    • GPR13
    • GPRV28
    • V28
    see all
  • Function
    Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1.
  • Tissue specificity
    Expressed in lymphoid and neural tissues.
  • Sequence similarities
    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization
    Cell membrane.
  • Information by UniProt

References

ab8124 has not yet been referenced specifically in any publications.

Publishing research using ab8124? Please let us know so that we can cite the reference in this datasheet.

Customer reviews and Q&As

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Question

Does this peptide block the binding of fractalkine to it's receptor? Also, do the related polyclonal antibodies ab8020, ab8021, or ab7201 block binding to or inhibit chemotazis mediated by fractalkine? thank you for your help Kristen M. Heers

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Answer

This peptide blocks the binding of the antibody -- Rabbit polyclonal to human CX3CR1 (extracellular) ab8020 -- to human CX3CR1. There is no evidence that this peptide blocks the binding of fractalkine to its receptor (i.e. binding of fractalkine to CX3CR1). With regard to the other polyclonal antibodies that you mention, again there is no evidence that they block binding to or inhibit chemotazis mediated by fractalkine

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